Non-flavonoid polyphenols in osteoporosis: preclinical evidence.
bone erosive diseases
epigenetics
osteoblast
osteoclast
osteoporosis
polyphenolic compounds
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
29
01
2021
revised:
22
03
2021
accepted:
22
03
2021
pubmed:
26
4
2021
medline:
9
2
2022
entrez:
25
4
2021
Statut:
ppublish
Résumé
The development of progressive osteopenia and osteoporosis (OP) is due to the imbalance between bone resorption and bone formation, determining a lower bone resistance, major risks of fractures, with consequent pain and functional limitations. Flavonoids, a class of polyphenols, have been extensively studied for their therapeutic activities against bone resorption, but less attention has been given to a whole series of molecules belonging to the polyphenolic compounds. However, these classes have begun to be studied for the treatment of OP. In this systematic review, comprehensive information is provided on non-flavonoid polyphenolic compounds, and we highlight pathways implicated in the action of these molecules that act often epigenetically, and their possible use for OP treatment and prevention.
Identifiants
pubmed: 33895073
pii: S1043-2760(21)00069-2
doi: 10.1016/j.tem.2021.03.008
pii:
doi:
Substances chimiques
Flavonoids
0
Polyphenols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-529Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.