Carbapenemase-producing Gram-negative bacteria in aquatic environments: a review.

Bacterial Proteins / genetics Carbapenems Gram-Negative Bacteria / genetics beta-Lactamases / genetics
Aquatic environment Carbapenemase Epidemiology Gram-negative bacilli

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
06 2021
Historique:
received: 10 11 2020
revised: 04 03 2021
accepted: 20 03 2021
pubmed: 26 4 2021
medline: 2 7 2021
entrez: 25 4 2021
Statut: ppublish

Résumé

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of choice with the broadest spectrum of activity and, in many cases, are the last-resort treatment for several bacterial infections. Carbapenemase-encoding genes, mainly carried by mobile genetic elements, are the main mechanism of resistance against carbapenems in GNB. These enzymes exhibit a versatile hydrolytic capacity and confer resistance to most β-lactam antibiotics. After being considered a clinical issue, increasing attention is being giving to the dissemination of such resistance mechanisms in the environment and especially through water. Aquatic environments are among the most significant microbial habitats on our planet, known as a favourable medium for antibiotic gene transfer, and they play a crucial role in the huge spread of drug resistance in the environment and the community. In this review, we present current knowledge regarding the spread of carbapenemase-producing isolates in different aquatic environments, which may help the implementation of control and prevention strategies against the spread of such dangerous resistant agents in the environment.

Identifiants

DOI: 10.1016/j.jgar.2021.03.024 PMID: 33895415
pubmed: 33895415
pii: S2213-7165(21)00092-8
doi: 10.1016/j.jgar.2021.03.024
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Carbapenems 0
beta-Lactamases EC 3.5.2.6
carbapenemase EC 3.5.2.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

287-309

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Zineb Cherak (Z)

Laboratoire de Génétique, Biotechnologie et Valorisation des Bio-ressources (GBVB), Faculté des Sciences Exactes et des Sciences de la Nature et de la Vie, Université Mohamed Khider, Biskra, Algeria.

Lotfi Loucif (L)

Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire (LBMBPC), Département de Microbiologie et de Biochimie, Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria. Electronic address: lotfiloucif@hotmail.fr.

Abdelhamid Moussi (A)

Laboratoire de Génétique, Biotechnologie et Valorisation des Bio-ressources (GBVB), Faculté des Sciences Exactes et des Sciences de la Nature et de la Vie, Université Mohamed Khider, Biskra, Algeria.

Jean-Marc Rolain (JM)

Aix-Marseille Université, IRD, MEPHI, Faculté de Médecine et de Pharmacie, Marseille, France; IHU Méditerranée Infection, Marseille, France; and Assistance Publique des Hôpitaux de Marseille, Marseille, France.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Carbapenemase-producing Gram-negative bacteria...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Carbapenemase-producing Gram-negative bacteria...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Carbapenemase-producing Gram-negative bacteria...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Carbapenemase-producing Gram-negative bacteria...