Transfusion burden following reduced intensity allogeneic hematopoietic cell transplantation: Impact of donor type.
Adolescent
Adult
Aged
Allografts
Blood Cell Count
Blood Platelets
Blood Transfusion
/ economics
Cord Blood Stem Cell Transplantation
Female
Graft Survival
HLA Antigens
/ analysis
Hematopoietic Stem Cell Transplantation
Hemorrhage
/ therapy
Histocompatibility
Humans
Infant, Newborn
Living Donors
Male
Middle Aged
Neutrophils
Parents
Procedures and Techniques Utilization
Siblings
Tissue Donors
Transplantation Conditioning
/ methods
Transplantation, Haploidentical
Unrelated Donors
haploidentical
hematopoietic stem cell transplantation
transfusion burden
transfusion independence
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
02
04
2021
received:
04
01
2021
accepted:
05
04
2021
pubmed:
27
4
2021
medline:
14
8
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
Transfusions are essential for allogeneic hematopoietic cell transplant (HCT), yet they are influenced by graft, donor, and other factors. We analyzed transfusions in 165 adult reduced intensity HCTs (2016-2019): HLA matched sibling donor (MSD) (n = 59), matched URD (n = 25), UCB (n = 33), and haploidentical (haplo, n = 48) detailing the cumulative incidence of platelet and RBC transfusion independence, total transfusions (day-10 to day+100) plus transfusion densities (per week) over 110 days. Platelet recovery to 20 × 10 The transplant donor influences the transfusion burden with greater platelet and RBC needs in haplo and UCB HCT which directly contributes to increased cost of care.
Sections du résumé
BACKGROUND
Transfusions are essential for allogeneic hematopoietic cell transplant (HCT), yet they are influenced by graft, donor, and other factors.
STUDY DESIGN
We analyzed transfusions in 165 adult reduced intensity HCTs (2016-2019): HLA matched sibling donor (MSD) (n = 59), matched URD (n = 25), UCB (n = 33), and haploidentical (haplo, n = 48) detailing the cumulative incidence of platelet and RBC transfusion independence, total transfusions (day-10 to day+100) plus transfusion densities (per week) over 110 days.
RESULTS
Platelet recovery to 20 × 10
DISCUSSION
The transplant donor influences the transfusion burden with greater platelet and RBC needs in haplo and UCB HCT which directly contributes to increased cost of care.
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2064-2074Subventions
Organisme : American Society of Hematology Visiting Scholar Program
Informations de copyright
© 2021 AABB.
Références
Warlick ED, DeFor TE, Bejanyan N, Holtan S, MacMillan M, Blazar BR, et al. Reduced-intensity conditioning followed by related and unrelated allografts for hematologic malignancies: expanded analysis and long-term follow-up. Biol Blood Marrow Transplant. 2019;25(1):56-62.
Solh M, Brunstein C, Morgan S, Weisdorf D. Platelet and red blood cell utilization and transfusion independence in umbilical cord blood and allogeneic peripheral blood hematopoietic cell transplants. Biol Blood Marrow Transplant. 2011;17(5):710-6.
Lin DY. Non-parametric inference for cumulative incidence functions in competing risks studies. Stat Med. 1997;16(8):901-10.
Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94(446):496-509.
Cameron AC, Trivedi PK. Regression analysis of count data. Cambridge: Cambridge University Press; 1998.
Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53(282):457-81.
Solves P, Sanz J, Gómez I, Puerta R, Arnao M, Montoro J, et al. Comparison of transfusion requirements in adult patients undergoing Haploidentical or single-unit umbilical cord blood stem cell transplantation. Eur J Haematol. 2019;103(3):172-7.
Desjonqueres A, Illiaquer M, Duquesne A, le Bris Y, Peterlin P, Guillaume T, et al. Longer delay of hematological recovery and increased transfusion needs after haploidentical compared to non-haploidentical stem cell transplantation. Bone Marrow Transplant. 2016;51(8):1150-2.
Yuan S, Yang D, Nakamura R, Zhuang L, al Malki MM, Karanes C, et al. Red blood cell and platelet transfusion support in the first 30 and 100 days after allogeneic hematopoietic cell transplant. Transfusion. 2020;60(10):2225-42.
Naithani R, Sachdev M, Rai R, Singh M. Packed red blood cells and platelet transfusion support in patients undergoing bone marrow transplantation: analysis of 82 cases. Indian J Hematol Blood Transfus. 2016;32(4):525-6.
Liesveld J, Pawlowski J, Chen R, Hyrien O, Debolt J, Becker M, et al. Clinical factors affecting engraftment and transfusion needs in SCT: a single-center retrospective analysis. Bone Marrow Transplant. 2013;48(5):691-7.
Prébet T, Ladaique P, Ferrando M, Chabannon C, Faucher C, de Lavallade H, et al. Platelet recovery and transfusion needs after reduced intensity conditioning allogeneic peripheral blood stem cell transplantation. Exp Hematol. 2010;38:55-60.
Datta SS, Basu S, Chandy M. An analysis of transfusion support in haematopoietic stem cell transplantation - report from a Centre in India. Transfus Apher Sci. 2015;53(3):373-7.
Gastecki K, Shanley R, Welbig J, Cohn C, Brunstein CG. Red blood cell product utilization in patients undergoing allogeneic stem cell transplantation. Transfusion. 2019;59(7):2301-7.