First report of Mycobacterium bovis in wild chacma baboons (Papio ursinus) at the human-wildlife interface area in Zambia.
MIRU-VNTR
Mycobacterium bovis
Zambia
baboons
human-wildlife-livestock interface
spoligotyping
tuberculosis
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
01
03
2021
received:
29
10
2020
pubmed:
27
4
2021
medline:
7
5
2022
entrez:
26
4
2021
Statut:
ppublish
Résumé
Mycobacterium bovis (M. bovis) causes tuberculosis in mammals and is a major public health threat worldwide. While M. bovis has been reported in humans, domestic and wild ruminants at the human-wildlife-livestock interface area in Zambia, there is paucity of information on the role of primates as reservoir hosts. We screened seven wild chacma baboons (Papio ursinus) for tuberculosis at the human-wildlife interface area in Lochinvar National Park in the Kafue Flats, Zambia. Following necropsy, lung tissue and associated lymph nodes with tuberculous-like lesions collected from four adult male baboons were prepared for Mycobacterium culture. The isolates were initially typed using the Mycobacterium tuberculosis complex-discrimination multiplex PCR assay and further characterized by spoligotyping and 26-loci MIRU-VNTR. Mycobacteria were isolated from all four animals and identified as M. bovis by PCR. On Spoligotyping, all isolates belonged to SB 0120 spoligotype, which is similar to what was previously reported in humans, cattle and Kafue lechwe antelopes in Kafue Flats ecosystem. Furthermore, on MIRU-VNTR typing, the baboon isolates clustered with cattle and Kafue lechwe isolates from the same catchment area. This finding intimates probable cross-species transmission of M. bovis in the Kafue Flats ecosystem. Due to the close interaction of baboons and humans at interface areas in Zambia, our results have potential implications for public health. Equally, this finding raises concerns for conservation.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1659-1662Subventions
Organisme : Grants-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
ID : 16H06429
Organisme : Grants-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
ID : 16H06431
Organisme : Grants-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
ID : 16K21723
Organisme : Japan Initiative for Global Research Network of Infectious Diseases (J-GRID) from Japan Agency for Medical Research and Development (AMED)
ID : JP19fm0108008
Organisme : AMED/Japan International Cooperation Agency (JICA) within the framework of the Science and Technology Research Partnership for Sustainable Development (SATREPS)
ID : JP19jm0110019
Organisme : Japan Society for the Promotion of Science (JSPS) KAKENHI
ID : 16H05805
Organisme : Department of National Parks and Wildlife under the Ministry of Tourism and Arts
Informations de copyright
© 2021 Wiley-VCH GmbH.
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