A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia.
Animals
Diabetes Mellitus
/ drug therapy
Humans
Hypoglycemic Agents
/ pharmacology
Japan
Medicine, Ayurvedic
Molecular Structure
Obesity
/ prevention & control
Plant Roots
/ chemistry
Plant Stems
/ chemistry
Randomized Controlled Trials as Topic
Salacia
/ chemistry
Sugar Alcohols
/ pharmacology
Sulfates
/ pharmacology
Thiosugars
/ pharmacology
Diabetes
Functional food
Neokotalanol
Salacia
Salacinol
α-glucosidase inhibitor
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
20
03
2021
accepted:
20
04
2021
pubmed:
27
4
2021
medline:
4
6
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (1) and neokotalanol (4), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia, from basic chemical and pharmacological research to their application and development as new functional food ingredients.
Identifiants
pubmed: 33900535
doi: 10.1007/s11418-021-01522-0
pii: 10.1007/s11418-021-01522-0
pmc: PMC8159842
doi:
Substances chimiques
Hypoglycemic Agents
0
Sugar Alcohols
0
Sulfates
0
Thiosugars
0
neokotalanol
0
salacinol
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
449-466Subventions
Organisme : Japan Society for the Promotion of Science (JP)
ID : 16K08313
Organisme : Japan Society for the Promotion of Science (JP)
ID : 18K06726
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