Exposure via biotransformation: Oxazepam reaches predicted pharmacological effect levels in European perch after exposure to temazepam.

Animals Biotransformation Hypnotics and Sedatives / metabolism Oxazepam / metabolism Perches / metabolism Temazepam / metabolism Water Pollutants, Chemical / metabolism
Accumulation Depuration Fish Metabolic transformation Metabolite Pharmaceutical Psychoactive drug

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
01 Jul 2021
Historique:
received: 20 01 2021
revised: 02 04 2021
accepted: 08 04 2021
pubmed: 27 4 2021
medline: 21 5 2021
entrez: 26 4 2021
Statut: ppublish

Résumé

It is generally expected that biotransformation and excretion of pharmaceuticals occurs similarly in fish and mammals, despite significant physiological differences. Here, we exposed European perch (Perca fluviatilis) to the benzodiazepine drug temazepam at a nominal concentration of 2 µg L

Identifiants

DOI: 10.1016/j.ecoenv.2021.112246 PMID: 33901781
pubmed: 33901781
pii: S0147-6513(21)00357-2
doi: 10.1016/j.ecoenv.2021.112246
pii:
doi:

Substances chimiques

Hypnotics and Sedatives 0
Water Pollutants, Chemical 0
Oxazepam 6GOW6DWN2A
Temazepam CHB1QD2QSS

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112246

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Daniel Cerveny (D)

Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Umeå, Sweden; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, Vodnany, Czech Republic. Electronic address: daniel.cerveny@slu.se.

Jerker Fick (J)

Department of Chemistry, Umeå University, Umeå, Sweden.

Jonatan Klaminder (J)

Department of Ecology and Environmental Science, Umeå University, Umeå, Sweden.

Michael G Bertram (MG)

Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Umeå, Sweden.

Tomas Brodin (T)

Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Umeå, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Exposure via biotransformation: Oxazepam...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Exposure via biotransformation: Oxazepam...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Hypnotiques et sédatifs › Exposure via biotransformation: Oxazepam...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Oxazépam › Exposure via biotransformation: Oxazepam...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Perciformes › Perches › Exposure via biotransformation: Oxazepam...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Témazépam › Exposure via biotransformation: Oxazepam...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Exposure via biotransformation: Oxazepam...