Single cell plasticity and population coding stability in auditory thalamus upon associative learning.
Acoustic Stimulation
Amygdala
/ cytology
Animals
Auditory Pathways
/ physiology
Auditory Perception
/ physiology
Cell Plasticity
/ physiology
Conditioning, Classical
/ physiology
Fear
/ physiology
Geniculate Bodies
/ cytology
Learning
/ physiology
Mice, Inbred C57BL
Neuronal Plasticity
/ physiology
Neurons
/ physiology
Thalamus
/ cytology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 04 2021
26 04 2021
Historique:
received:
08
04
2020
accepted:
01
03
2021
entrez:
27
4
2021
pubmed:
28
4
2021
medline:
11
5
2021
Statut:
epublish
Résumé
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains unknown. Using a miniature microscope imaging approach, we monitor the activity of populations of auditory thalamus (medial geniculate body) neurons in freely moving mice upon fear conditioning. We find that single cells exhibit mixed selectivity and heterogeneous plasticity patterns to auditory and aversive stimuli upon learning, which is conserved in amygdala-projecting medial geniculate body neurons. Activity in auditory thalamus to amygdala-projecting neurons stabilizes single cell plasticity in the total medial geniculate body population and is necessary for fear memory consolidation. In contrast to individual cells, population level encoding of auditory stimuli remained stable across days. Our data identifies auditory thalamus as a site for complex neuronal plasticity in fear learning upstream of the amygdala that is in an ideal position to drive plasticity in cortical and limbic brain areas. These findings suggest that medial geniculate body's role goes beyond a sole relay function by balancing experience-dependent, diverse single cell plasticity with consistent ensemble level representations of the sensory environment to support stable auditory perception with minimal affective bias.
Identifiants
pubmed: 33903596
doi: 10.1038/s41467-021-22421-8
pii: 10.1038/s41467-021-22421-8
pmc: PMC8076296
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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