Emerging mechanisms of immunocoagulation in sepsis and septic shock.
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
26
12
2020
revised:
31
03
2021
accepted:
01
04
2021
pubmed:
29
4
2021
medline:
6
7
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
Sepsis and septic shock driven by microbial infections are still among the most challenging health problems, causing 11 million deaths worldwide every year. How does the host's response to pathogen infections effectively restore homeostasis instead of precipitating pathogenic and potentially fatal feedforward reactions? Recently, there have been significant new advances in our understanding of the interface between mammalian immunity and coagulation ('immunocoagulation') and its impact on sepsis. In particular, the release and activation of F3 (the main initiator of coagulation) from and on myeloid or epithelial cells is facilitated by activating inflammasomes and consequent gasdermin D (GSDMD)-mediated pyroptosis, coupled to signaling via high mobility group box 1 (HMGB1), stimulator of interferon response CGAMP interactor 1 (STING1), or sequestosome 1 (SQSTM1). Pharmacological modulation of the immunocoagulation pathways emerge as novel and potential therapeutic strategies for sepsis.
Identifiants
pubmed: 33906793
pii: S1471-4906(21)00072-7
doi: 10.1016/j.it.2021.04.001
pmc: PMC8436187
mid: NIHMS1737551
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Phosphate-Binding Proteins
0
Caspases, Initiator
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
508-522Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127791
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No conflicts of interest to declare.
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