NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse.
addictive phenotypes
glutamate receptors
mesolimbic system
mice
sugar
transgenic models
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
Historique:
received:
22
01
2021
revised:
01
04
2021
accepted:
16
04
2021
pubmed:
29
4
2021
medline:
3
7
2021
entrez:
28
4
2021
Statut:
epublish
Résumé
Glutamatergic input via NMDA and AMPA receptors within the mesolimbic dopamine (DA) pathway plays a critical role in the development of addictive behavior and relapse toward drugs of abuse. Although well-established for drugs of abuse, it is not clear whether glutamate receptors within the mesolimbic system are involved in mediating chronic consumption and relapse following abstinence from a non-drug reward. Here, we evaluated the contribution of mesolimbic glutamate receptors in mediating chronic sugar consumption and the sugar-deprivation effect (SDE), which is used as a measure of relapse-like behavior following abstinence. We studied four inducible mutant mouse lines lacking the GluA1 or GluN1 subunit in either DA transporter (DAT) or D1R-expressing neurons in an automated monitoring system for free-choice sugar drinking in the home cage. Mice lacking either GluA1 or GluN1 in D1R-expressing neurons (
Identifiants
pubmed: 33906970
pii: ENEURO.0029-21.2021
doi: 10.1523/ENEURO.0029-21.2021
pmc: PMC8143023
pii:
doi:
Substances chimiques
Dietary Sugars
0
Receptors, Dopamine D1
0
Receptors, N-Methyl-D-Aspartate
0
Sugars
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 Wei et al.
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