Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE
Animals
Apolipoprotein B-100
/ antagonists & inhibitors
Atherosclerosis
/ immunology
Autoantibodies
/ immunology
Female
Fusion Proteins, bcr-abl
/ immunology
Immunoglobulin G
/ metabolism
Lipoproteins, LDL
/ metabolism
Malaria Vaccines
/ immunology
Malondialdehyde
/ analogs & derivatives
Mice
Peptide Fragments
/ immunology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 04 2021
27 04 2021
Historique:
received:
19
11
2020
accepted:
09
04
2021
entrez:
28
4
2021
pubmed:
29
4
2021
medline:
28
10
2021
Statut:
epublish
Résumé
Atherosclerotic plaques are characterized by an accumulation and subsequent oxidation of LDL, resulting in adaptive immune responses against formed or exposed neoepitopes of the LDL particle. Autoantibodies against native p210, the 3136-3155 amino acid sequence of the LDL protein apolipoprotein B-100 (apoB100) are common in humans and have been associated with less severe atherosclerosis and decreased risk for cardiovascular events in clinical studies. However, whether apoB100 native p210 autoantibodies play a functional role in atherosclerosis is not known. In the present study we immunized apoE
Identifiants
pubmed: 33907226
doi: 10.1038/s41598-021-88430-1
pii: 10.1038/s41598-021-88430-1
pmc: PMC8079692
doi:
Substances chimiques
Apob protein, mouse
0
Apolipoprotein B-100
0
Autoantibodies
0
Immunoglobulin G
0
Lipoproteins, LDL
0
Malaria Vaccines
0
PADRE 45
0
Peptide Fragments
0
malondialdehyde-low density lipoprotein, mouse
0
Malondialdehyde
4Y8F71G49Q
Fusion Proteins, bcr-abl
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9022Références
J Immunol. 2000 Feb 1;164(3):1625-33
pubmed: 10640784
Eur Heart J. 2008 Sep;29(18):2218-26
pubmed: 18664466
Biochem Biophys Res Commun. 2005 Dec 30;338(4):1982-9
pubmed: 16288717
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):454-60
pubmed: 12615659
J Exp Med. 2009 Oct 26;206(11):2397-406
pubmed: 19841087
Am J Pathol. 2000 Dec;157(6):1819-24
pubmed: 11106554
Atherosclerosis. 2014 Jan;232(1):242-8
pubmed: 24401246
Immunol Lett. 2004 Apr 15;92(3):259-68
pubmed: 15081621
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):879-84
pubmed: 12649092
Lancet. 2020 Mar 7;395(10226):785-794
pubmed: 31492501
Histochem J. 2001 Apr;33(4):227-9
pubmed: 11550804
Am J Transl Res. 2018 Jun 15;10(6):1817-1828
pubmed: 30018722
PLoS One. 2012;7(2):e30780
pubmed: 22347402
J Intern Med. 2000 Mar;247(3):371-80
pubmed: 10762454
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3893-7
pubmed: 7732003
J Clin Invest. 1997 Jun 1;99(11):2752-61
pubmed: 9169506
EMBO Mol Med. 2012 Oct;4(10):1072-86
pubmed: 23027612
J Clin Invest. 1998 Jun 15;101(12):2658-64
pubmed: 9637699
Circulation. 2005 Aug 16;112(7):1054-62
pubmed: 16103256
Immunity. 1994 Dec;1(9):751-61
pubmed: 7895164
J Interferon Cytokine Res. 2002 Jun;22(6):661-70
pubmed: 12162876
Arterioscler Thromb. 1994 Jan;14(1):32-40
pubmed: 7506053
Nature. 2002 Jun 13;417(6890):750-4
pubmed: 12066187
J Intern Med. 2008 Dec;264(6):563-70
pubmed: 18783480
Diabetologia. 2009 Jul;52(7):1426-33
pubmed: 19448981
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1596-601
pubmed: 15665085
Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):765-71
pubmed: 26916732
Circulation. 2004 Oct 5;110(14):2047-52
pubmed: 15451805
Atherosclerosis. 2009 Jul;205(1):96-100
pubmed: 19150065
J Clin Invest. 1955 Sep;34(9):1345-53
pubmed: 13252080
J Intern Med. 2011 May;269(5):546-56
pubmed: 21114693
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):872-8
pubmed: 12649091
Physiol Rep. 2017 Jul;5(14):
pubmed: 28716818
Heart Lung Circ. 2013 Jun;22(6):399-411
pubmed: 23541627
Sci Rep. 2019 Apr 12;9(1):5964
pubmed: 30979943