Effects of the prevention of medication-related osteonecrosis of the jaw by local administration of a dental pulp stem cell-conditioned medium to the rat tooth extraction socket.
Atelocollagen
Dental pulp stem cell (DPSC)
Dental pulp stem cell-conditioned medium (DPSC-CM)
MRONJ
Vascular endothelial growth factor (VEGF)
Journal
Odontology
ISSN: 1618-1255
Titre abrégé: Odontology
Pays: Japan
ID NLM: 101134822
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
21
12
2020
accepted:
08
04
2021
pubmed:
29
4
2021
medline:
28
8
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
The onset of osteonecrosis of the jaw, which is a side effect of bisphosphonates, often develops after tooth extraction; measures for its prevention have not yet been established. While treatment with systemic administration of bone marrow stem cell-derived conditioned medium for medication-related osteonecrosis of the jaw (MRONJ) has been reported, its preventive effects have not been clarified yet, and the high degree of invasiveness of bone marrow fluid collection remains an issue. Therefore, we created a rat model of MRONJ using BP zoledronic acid, used a dental pulp stem cell-conditioned medium (DPSC-CM), which can be collected relatively easily, and locally applied it to the tooth extraction socket with atelocollagen and gelatin sponges. The preventive effect on the onset of MRONJ was subsequently examined. The results demonstrated that the bone exposure width of the extraction socket was reduced, and the mucosal covering was promoted in the atelocollagen + DPSC-CM group as compared with the other groups. Furthermore, histological results indicated a decrease in the number of empty bone lacunae, whereas immunohistochemical staining revealed the presence of many vascular endothelial growth factor (VEGF)-positive cells. Moreover, the results of the investigation of the sustained release of atelocollagen using VEGF indicated the release of VEGF over time. Our results suggest that local administration of DPSC-CM using atelocollagen may be a useful method for the prevention of MRONJ triggered by tooth extraction.
Identifiants
pubmed: 33907964
doi: 10.1007/s10266-021-00607-2
pii: 10.1007/s10266-021-00607-2
doi:
Substances chimiques
Bone Density Conservation Agents
0
Culture Media, Conditioned
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
836-844Informations de copyright
© 2021. The Society of The Nippon Dental University.
Références
Jang HW, Kim JW, Cha IH. Development of animal model for bisphosphonate-related osteonecrosis of the jaw (BRONJ). Maxillofac Plastic Reconstruct Surg. 2015;37:18.
doi: 10.1186/s40902-015-0020-6
Kobayashi Y, Hiraga T, Ueda A, Wang L, Matsumoto-Nakano M, Hata K, Yatani H, Yoneda T. Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes without causing osteonecrosis of the jaw, in mice. J Bone Miner Metab. 2010;28:165–75.
doi: 10.1007/s00774-009-0128-9
Tezuka R, Tanaka A. Jawbone changes in sodium zoledronic acid and dexamethasone-treated rats. J Hard Tissue Biol. 2016;25:383–94.
doi: 10.2485/jhtb.25.383
Sumi K, Abe T, Kunimatsu R, Oki N, Tsuka Y, Awada T, Nakajima K, Ando K, Tanimoto K. The effect of mesenchymal stem cells on chemotaxis of osteoclast precursor cells. J Oral Sci. 2018;60:221–5.
doi: 10.2334/josnusd.17-0187
Ogata K, Katagiri W, Osugi M, Kawai T, Sugimura Y, Hibi H, Nakamura S, Ueda M. Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model. Bone. 2015;74:95–105.
doi: 10.1016/j.bone.2015.01.011
Sasso RC, LeHuec JC, Shaffrey C, Spine Interbody Research Group. Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment. J Spinal Disord Tech. 2005; 18: 77–81.
Sato M, Ishidai S, Iwasa S, Takei H. Characterization of cultured human mesenchymal stem cells from deciduous and permanent teeth. Jap J Pedodont. 2014;52:417–24.
Abe F, Takahashi H, Tanaka A. Investigation on the action and effect of culture supernatant of human dental pulp stem cells using rats with medication-related osteonecrosis of the jaw. J Hard Tissue Biol. 2019;28:349–58.
doi: 10.2485/jhtb.28.349
Bronckaers A, Hilkens P, Fanton Y, Struys T, Gervois P, Politis C, Martens W, Lambrichts I. Angiogenic properties of human dental pulp stem cells. PLoS ONE. 2013;8:e71104.
doi: 10.1371/journal.pone.0071104
Doppelt O, Cohen G, Tamari T, Elimekech R, Sabbah N, Zigdon-Giladi H. Endothelial progenitors increase vascularization and improve fibroblasts function that prevent medication-related osteonecrosis of the jaw. Oral Dis. 2020;26:1.
doi: 10.1111/odi.13412
Imada M, Yagyuu T, Ueyama Y, Maeda M, Yamamoto K, Kurokawa S, Jo J, Tabata Y, Tanaka Y, Kirita T. Prevention of tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaws with basic fibroblast growth factor: An experimental study in rats. PLoS ONE. 2019;14:e0211928.
doi: 10.1371/journal.pone.0211928
Adachi N, Ayukawa Y, Yasunami N, Furuhashi A, Imai M, Sanda K, Atsuta I, Koyano K. Preventive effect of fluvastatin on the development of medication-related osteonecrosis of the jaw. Sci Rep. 2020;10:5620.
doi: 10.1038/s41598-020-61724-6
Kuroda Y, Kawai T, Goto K, Matsuda S. Clinical application of injectable growth factor for bone regeneration: a systematic review. Inflamm Regen. 2019;39:20.
doi: 10.1186/s41232-019-0109-x
Alonso-Rodriguez E, González-Martín-Moro J, Cebrián-Carretero JL, Del Castillo JL, Pozo-Kreilinger JJ, Ruiz-Bravo E, García-Arranz M, Hernández-Godoy J, Burgueño M. Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model. Med Oral Patol Oral Cir Bucal. 2019;24:e529–36.
pubmed: 31232388
pmcid: 6667013
Kanematsu A, Marui A, Yamamoto S, Ozeki M, Hirano Y, Yamamoto M, Ogawa O, Komeda M, Tabata Y. Type I collagen can function as a reservoir of basic fibroblast growth factor. J Contorol Release. 2004;99:281–92.
doi: 10.1016/j.jconrel.2004.07.008
Abe Y, Iba K, Sasaki K, Chiba H, Kanaya K, Kawamata T, Oda K, Amizuka N, Sasaki M, Yamashita T. Inhibitory effect of bisphosphonate on osteoclast function contributes to improved skeletal pain in ovariectomized mice. J Bone Miner Metab. 2015;33:125–34.
doi: 10.1007/s00774-014-0574-x
Pettway GJ, Meganck JA, Koh AJ, Keller ET, Goldstein SA, McCauley LK. Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation. Bone. 2008;42:806–18.
doi: 10.1016/j.bone.2007.11.017
Hata S. Effect of oral administration of simvastatin on bone regeneration process in ovariectomized rat. J Hard Tissue Biol. 2009;18:47–56.
doi: 10.2485/jhtb.18.45
Vidal-Gutiérrez X, Gómez-Clavel JF, Gaitán-Cepeda LA. Dental extraction following zoledronate, induces osteonecrosis in rat’s jaw. Med Oral Patol Oral Cir Bucal. 2017;22:e177.
pubmed: 28160593
pmcid: 5359702
Williams DW, Lee C, Kim T, Yagita H, Wu H, Park S, Yang P, Liu H, Shi S, Shin KH, Kang MK, Park NH, Kim RH. Impaired bone resorption and woven bone formation are associated with development of osteonecrosis of the jaw-like lesions by bisphosphonate and anti-receptor activator of NF-κB ligand antibody in mice. Am J Pathol. 2014;184:30843093.
doi: 10.1016/j.ajpath.2014.07.010
Ando Y, Matsubara K, Ishikawa J, Fujio M, Shohara R, Hibi H, Ueda M, Yamamoto A. Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms. Bone. 2014;61:82–90.
doi: 10.1016/j.bone.2013.12.029
Kawai T, Katagiri W, Osugi M, Sugimura Y, Hibi H, Ueda M. Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration. Cytotherapy. 2015;17:369–81.
doi: 10.1016/j.jcyt.2014.11.009
Alge DL, Zhou D, Adams LL, Wyss BK, Shadday MD, Woods EJ, Gabriel Chu TM, Goebel WS. Donor-matched comparison of dental pulp stem cells and bone marrow-derived mesenchymal stem cells in a rat model. J Tissue Eng Reg Med. 2010;4:73–81.
Abraham S, Rangaswamy SP, Chinnaiah A. Evaluation of recombinant human vascular endothelial growth factor VEGF121-loaded poly-l-lactide microparticles as a controlled release delivery system. Turk J Biol. 2020;44:34–47.
pubmed: 32123494
pmcid: 7049456
Tabata Y, Ikada Y. Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials. 1999;20:2169–74.
doi: 10.1016/S0142-9612(99)00121-0
Gao SY, Lin RB, Huang SH, Liang YH, Li X, Zhang SE, Ouyang DQ, Li K, Zheng GS, Liao GQ. PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis. Bone. 2019;1:115117.
Basso FG, Turrioni APS, Hebling J, de Souza Costa CA. Effects of zoledronic acid on odontoblast-like cells. Arch Oral Biol. 2013;58:467–73.
doi: 10.1016/j.archoralbio.2012.09.016
Cankaya M, Senel FC, Duman MK, Muci E, Dayisoylu EH, Balaban F. The effects of chronic zoledronate usage on the jaw and long bones evaluated using RANKL and osteoprotegerin levels in an animal model. Int J Oral Maxillofac Surg. 2013;42:1134–9.
doi: 10.1016/j.ijom.2013.02.008
Basso FG, Turrioni AP, Hebling J, de Souza Costa CA. Zoledronic acid inhibits human osteoblast activities. Gerontology. 2013;59:534–41.
doi: 10.1159/000351194
Tamari T, Elimelech R, Cohen G, Cohen T, Doppelt O, Eskander-Hashoul L, Zigdon-Giladi H. Endothelial progenitor cells inhibit jaw osteonecrosis in a rat model: a major adverse effect of bisphosphonate therapy. Sci Rep. 2019;9:18896.
doi: 10.1038/s41598-019-55383-5
Hu K, Olsen BR. Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. J Clin Invest. 2016;126:509–26.
doi: 10.1172/JCI82585
Tarkka T, Sipola A, Jämsä T, Soini Y, Ylä-Herttuala S, Tuukkanen J, Hautala T. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med. 2003;5:560–6.
doi: 10.1002/jgm.392
Hiraki T, Kunimatsu R, Nakajima K, Abe T, Yamada S, Rikitake K, Tanimoto K. Stem cell-derived conditioned media from human exfoliated deciduous teeth promote bone regeneration. Oral Dis. 2020;26:381–90.
doi: 10.1111/odi.13244