Titanium implant alters the effect of zoledronic acid on the behaviour of endothelial cells.
BRONJ
angiogenesis
bisphosphonate-related osteonecrosis of the jaw
human umbilical vein endothelial cell
titanium implant
zoledronic acid
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
revised:
03
04
2021
received:
17
01
2021
accepted:
16
04
2021
pubmed:
29
4
2021
medline:
15
9
2022
entrez:
28
4
2021
Statut:
ppublish
Résumé
To evaluate the effect of zoledronic acid (ZA) on human umbilical vein endothelial cells (HUVECs) attached to different surfaces. A total of three groups were evaluated in this study: sandblasting and acid etching (SLA) + HUVECs; mechanically polished (MP) + HUVECs; and plastic cell culture plates + HUVECs. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, surface roughness and water contact angle were tested for titanium surface characterisation. ZA was added at different concentrations (0, 1, 10, 50 and 100 μM). Cell adhesion, proliferation, viability, apoptosis and gene expression were evaluated. Mechanically polished and SLA surfaces showed negative effects on cell adhesion and proliferation and promoted cell apoptosis with 100 μM ZA (p < .05). The highest expression of intercellular adhesion molecule-1 (ICAM-1) and angiopoietin-1 was found on SLA surfaces (p < .01). The lowest expression of platelet-endothelial cell adhesion molecule-1 and ICAM-1 was found on MP surfaces (p < .05). A significant decrease in von Willebrand factor was detected on MP and SLA surfaces (p < .001). Zoledronic acid has an anti-angiogenic effect on HUVECs attached to titanium implants, while the SLA surface might stimulate HUVECs to express angiogenic and adhesive factor genes despite ZA treatment.
Substances chimiques
Intercellular Adhesion Molecule-1
126547-89-5
Zoledronic Acid
6XC1PAD3KF
Titanium
D1JT611TNE
Types de publication
Journal Article
Langues
eng
Pagination
1968-1978Subventions
Organisme : Science and Technology Major Project of Guangdong Province
ID : 2017B090912004
Organisme : the Young Teacher Training Program of Sun Yat-sen University
ID : 19ykpy84
Informations de copyright
© 2021 Wiley Periodicals LLC.
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