Chitosan coated pH-responsive metal-polyphenol delivery platform for melanoma chemotherapy.
Animals
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Cell Line, Tumor
Chitosan
/ chemistry
Drug Carriers
/ chemistry
Drug Delivery Systems
/ methods
Drug Liberation
Hydrogen-Ion Concentration
Ki-67 Antigen
/ metabolism
Melanoma
/ drug therapy
Metal Nanoparticles
/ chemistry
Mice
Particle Size
Platelet Endothelial Cell Adhesion Molecule-1
/ metabolism
Polyphenols
/ chemistry
Taxoids
/ chemistry
Tumor Microenvironment
/ drug effects
Chemotherapy
Chitosan
Melanoma
Metal-polyphenol
pH-responsiveness
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
07
11
2020
revised:
08
02
2021
accepted:
25
03
2021
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
22
9
2021
Statut:
ppublish
Résumé
The safe and effective drug delivery system is important for cancer therapy. Here in, we first constructed a delivery system Cabazitaxel(Cab)@MPN/CS between metal-polyphenol (MPN) and chitosan (CS) to deliver Cab for melanoma therapy. The preparation process is simple, green, and controllable. After introducing CS coating, the drug loading was improved from 7.56 % to 9.28 %. Cab@MPN/CS NPs released Cab continuously under acid tumor microenvironment. The zeta potential of Cab@MPN/CS NPs could be controlled by changing the ratio of Cab@MPN and CS solutions. The positively charged Cab@MPN/CS accelerate B16F10 cell internalization. After internalized, Cab@MPN/CS NPs could escape from lysosomes via the proton sponge effect. The permeability of CS promotes the penetration of Cab@MPN/CS to the deeper B16F10 tumor spheroids. In vivo results showed that Cab@MPN/CS NPs have a longer retention time in tumor tissues and significantly inhibit tumor growth by up-regulating TUNEL expression and down-regulating KI67 and CD31 expression. Thus, this delivery system provides a promising strategy for the tumor therapy in clinic.
Identifiants
pubmed: 33910734
pii: S0144-8617(21)00387-8
doi: 10.1016/j.carbpol.2021.118000
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Ki-67 Antigen
0
Platelet Endothelial Cell Adhesion Molecule-1
0
Polyphenols
0
Taxoids
0
cabazitaxel
51F690397J
Chitosan
9012-76-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118000Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.