Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants.
Chitosan
Immune mechanism
Immunostimulatory activities
Quaternized chitosan
Vaccine adjuvant
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
24
11
2020
revised:
01
04
2021
accepted:
03
04
2021
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
29
9
2021
Statut:
ppublish
Résumé
Vaccines have always been the most effective preventive treatment. Advancements in the field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines to enhance immunogenicity and induce a stronger immune response. Chitosan fascinated considerable attention as vaccine adjuvant due to its unique physicochemical and biological properties. Many studies have shown that chitosan and its derivatives can effectively activate antigen-presenting cells and induce cytokine stimulation to produce an effective immune response and promote the balance of Th1/Th2 response. Among many derivatives, the quaternized chitosan performs better. This review presents the main factors affecting the adjuvant performance of chitosan and quaternized chitosan firstly. Then, we introduced not only the immune response they may cause, but also their metabolic research in detail. Furthermore, their future prospects are forecasted. Overall, chitosan and quaternized chitosan are both promising adjuvant materials, and quaternized chitosan shows greater potential.
Identifiants
pubmed: 33910752
pii: S0144-8617(21)00437-9
doi: 10.1016/j.carbpol.2021.118050
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Vaccines
0
Chitosan
9012-76-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118050Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.