Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model.
bone infection
doxycycline
local antibiotics
prevention
prosthetic joint infection
tobramycin
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
15
12
2020
received:
01
09
2020
accepted:
12
04
2021
pubmed:
30
4
2021
medline:
19
4
2022
entrez:
29
4
2021
Statut:
ppublish
Résumé
We studied systemic ceftriaxone, and free/local tobramycin and doxycycline in a controlled rat model representing a generic acute exogenous joint infection. We hypothesized that evidence of infection (quantitative colony forming units [CFU], qualitative scanning electron microscopy [SEM], histopathology) (1a) would be reduced with local versus systemic antibiotic, (1b) any antibiotic would be superior to control, (2) there would be a difference among antibiotics, and (3) antibiotic would not be detectable in serum at 4-week euthanasia. Study groups included infected and noninfected (1) control (no treatment), (2) systemic ceftriaxone (daily), (3) local tobramycin, and (4) local doxycycline (10 rats/group; power = 0.8). With IACUC approval, a reliable acute exogenous joint infection was created by slowly injecting 50-μl, 10
Substances chimiques
Anti-Bacterial Agents
0
Ceftriaxone
75J73V1629
Doxycycline
N12000U13O
Tobramycin
VZ8RRZ51VK
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
429-438Subventions
Organisme : NIAID NIH HHS
ID : R21 AI115416
Pays : United States
Informations de copyright
© 2021 Orthopaedic Research Society. Published by Wiley Periodicals LLC.
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