Cervical spinal injury compromises caudal spinal tissue oxygenation and undermines acute intermittent hypoxia-induced phrenic long-term facilitation.

Animals Cervical Cord / injuries Hypoxia / metabolism Long-Term Potentiation / physiology Oxygen Consumption / physiology Phrenic Nerve / physiology Rats Rats, Sprague-Dawley Spinal Cord Injuries / complications
Acute intermittent hypoxia Adenosine Phrenic long-term facilitation Spinal tissue oxygenation

Journal

Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712

Informations de publication

Date de publication:
08 2021
Historique:
received: 18 02 2021
revised: 12 04 2021
accepted: 22 04 2021
pubmed: 30 4 2021
medline: 12 10 2021
entrez: 29 4 2021
Statut: ppublish

Résumé

An important model of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent increase in phrenic burst amplitude following acute intermittent hypoxia (AIH). Moderate AIH elicits pLTF by a serotonin-dependent mechanism known as the Q pathway to phrenic motor facilitation. In contrast, severe AIH (greater hypoxemia) increases spinal adenosine accumulation and activates phrenic motor neuron adenosine 2A receptors, thereby initiating a distinct mechanism of plasticity known as the S pathway. Since the Q and S pathways interact via mutual cross-talk inhibition, the balance between spinal serotonin release and adenosine accumulation is an important pLTF regulator. Spinal injury decreases spinal tissue oxygen pressure (PtO

Identifiants

DOI: 10.1016/j.expneurol.2021.113726 PMID: 33915165 PMC: PMC8327493
pubmed: 33915165
pii: S0014-4886(21)00132-1
doi: 10.1016/j.expneurol.2021.113726
pmc: PMC8327493
mid: NIHMS1722496
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113726

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL147554
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Références

J Physiol. 2009 Nov 15;587(Pt 22):5469-81
pubmed: 19805745
Science. 2019 Jul 19;365(6450):
pubmed: 31221773
Acta Neuropathol. 2018 Oct;136(4):507-523
pubmed: 30097696
Exp Neurol. 2015 Apr;266:1-10
pubmed: 25687551
Exp Neurol. 2020 Nov;333:113429
pubmed: 32735873
J Neurophysiol. 2017 Feb 1;117(2):836-845
pubmed: 27927784
Exp Neurol. 2021 Apr;338:113609
pubmed: 33460645
Front Physiol. 2021 Feb 24;12:573385
pubmed: 33716760
J Physiol. 2005 Sep 1;567(Pt 2):599-611
pubmed: 15932891
J Physiol Pharmacol. 1995 Sep;46(3):259-71
pubmed: 8527808
J Neurophysiol. 2015 Sep;114(3):1784-91
pubmed: 26224775
J Appl Physiol (1985). 2019 Aug 1;127(2):432-443
pubmed: 31219768
Respir Physiol Neurobiol. 2019 Jul;265:19-23
pubmed: 30639504
Am J Physiol. 1981 Aug;241(2):H235-42
pubmed: 6791511
Respir Physiol Neurobiol. 2018 Oct;256:50-57
pubmed: 28549897
J Physiol. 2010 Jan 1;588(Pt 1):255-66
pubmed: 19900961
Respir Physiol Neurobiol. 2016 Jun;226:81-6
pubmed: 26724605
J Neurosci. 2002 Jul 15;22(14):6239-46
pubmed: 12122082
J Physiol. 2002 Oct 1;544(Pt 1):161-70
pubmed: 12356889
J Appl Physiol (1985). 2012 May;112(10):1678-88
pubmed: 22403346
J Neurotrauma. 2014 Dec 15;31(24):1975-84
pubmed: 25003645
J Neurosci. 2016 Jul 27;36(30):7877-85
pubmed: 27466333
Adv Exp Med Biol. 2010;669:225-30
pubmed: 20217354
J Neurochem. 2019 Sep;150(6):648-665
pubmed: 31106417
J Cardiovasc Pharmacol. 1990;15 Suppl 7:S35-41
pubmed: 1702485
Nat Med. 2017 Jun;23(6):733-741
pubmed: 28459438
Exp Neurol. 2006 Jul;200(1):74-81
pubmed: 16647702
J Appl Physiol (1985). 2020 Mar 1;128(3):523-533
pubmed: 31971473
Respir Physiol. 1996 Jul;104(2-3):251-60
pubmed: 8893371
Neural Regen Res. 2016 Feb;11(2):189-94
pubmed: 27073353
Nat Neurosci. 2004 Jan;7(1):48-55
pubmed: 14699417
J Physiol. 2019 Jan;597(2):481-498
pubmed: 30382587
J Appl Physiol (1985). 2005 Mar;98(3):838-44
pubmed: 15531560
Br J Pharmacol. 2010 Dec;161(8):1806-16
pubmed: 20735412
Respir Physiol. 1980 Jul;41(1):87-103
pubmed: 6771859
Exp Neurol. 2020 Dec;334:113465
pubmed: 32949571
Stroke. 1974 Sep-Oct;5(5):630-9
pubmed: 4472361
Ann N Y Acad Sci. 2013 Mar;1279:143-53
pubmed: 23531012
Br J Pharmacol. 2011 Sep;164(1):132-44
pubmed: 21410685
J Neurosci. 2005 Mar 16;25(11):2925-32
pubmed: 15772352
Exp Neurol. 2017 Jan;287(Pt 2):93-101
pubmed: 27079999
Am J Physiol. 1993 Oct;265(4 Pt 2):R811-9
pubmed: 8238451
Respir Physiol. 1980 Dec;42(3):171-88
pubmed: 6452673
Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R709-R715
pubmed: 29384698

Auteurs

Raphael R Perim (RR)

Breathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

Elisa J Gonzalez-Rothi (EJ)

Breathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

Gordon S Mitchell (GS)

Breathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: gsmitche@phhp.ufl.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Moelle cervicale › Cervical spinal injury compromises caudal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Métabolisme › Consommation d'oxygène › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Plexus cervical › Nerf phrénique › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Cervical spinal injury compromises caudal...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Cervical spinal injury compromises caudal...