Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets.
Cholesterol
Lipid homeostasis
Mevalonate pathway inhibitors
SARS-CoV-2
Statins
Viral infections
Journal
Progress in lipid research
ISSN: 1873-2194
Titre abrégé: Prog Lipid Res
Pays: England
ID NLM: 7900832
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
17
03
2021
revised:
22
04
2021
accepted:
23
04
2021
pubmed:
30
4
2021
medline:
27
5
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
Despite encouraging progresses achieved in the management of viral diseases, efficient strategies to counteract infections are still required. The current global challenge highlighted the need to develop a rapid and cost-effective strategy to counteract the SARS-CoV-2 pandemic. Lipid metabolism plays a crucial role in viral infections. Viruses can use the host lipid machinery to support their life cycle and to impair the host immune response. The altered expression of mevalonate pathway-related genes, induced by several viruses, assures survival and spread in host tissue. In some infections, statins, HMG-CoA-reductase inhibitors, reduce cholesterol in the plasma membrane of permissive cells resulting in lower viral titers and failure to internalize the virus. Statins can also counteract viral infections through their immunomodulatory, anti-inflammatory and anti-thrombotic effects. Beyond statins, interfering with the mevalonate pathway could have an adjuvant effect in therapies aimed at mitigating endothelial dysfunction and deregulated inflammation in viral infection. In this review we depicted the historical and current evidence highlighting how lipid homeostasis and mevalonate pathway targeting represents a valid approach to rapidly neutralize viruses, focusing our attention to their potential use as effective targets to hinder SARS-CoV-2 morbidity and mortality. Pros and cons of statins and Mevalonate-pathway inhibitors have been also dissected.
Identifiants
pubmed: 33915202
pii: S0163-7827(21)00015-1
doi: 10.1016/j.plipres.2021.101099
pmc: PMC8074527
pii:
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Hypolipidemic Agents
0
Mevalonic Acid
S5UOB36OCZ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101099Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
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