COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Adult Aged Aged, 80 and over Atlases as Topic Autopsy Biological Specimen Banks COVID-19 / genetics Endothelial Cells Epithelial Cells / pathology Female Fibroblasts Genome-Wide Association Study Heart / virology Humans Inflammation / pathology Kidney / pathology Liver / pathology Lung / pathology Male Middle Aged Myocardium / pathology Organ Specificity Phagocytes Pulmonary Alveoli / pathology RNA, Viral / analysis Regeneration SARS-CoV-2 / immunology Single-Cell Analysis Viral Load

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2021
Historique:
received: 16 11 2020
accepted: 19 04 2021
pubmed: 30 4 2021
medline: 9 7 2021
entrez: 29 4 2021
Statut: ppublish

Résumé

COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure

Identifiants

DOI: 10.1038/s41586-021-03570-8 PMID: 33915569 PMC: PMC8919505
pubmed: 33915569
doi: 10.1038/s41586-021-03570-8
pii: 10.1038/s41586-021-03570-8
pmc: PMC8919505
mid: NIHMS1771808
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107-113

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R37 MH107649
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026933
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA222663
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA017729
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NHLBI NIH HHS
ID : UH3 HL141797
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107649
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101244
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA020744
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA258829
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA225088
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009379
Pays : United States
Organisme : NCI NIH HHS
ID : DP2 CA247831
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Toni M Delorey (TM)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0001-6614-3803

Carly G K Ziegler (CGK)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Program in Health Sciences & Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA, USA.
Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA.

Graham Heimberg (G)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Rachelly Normand (R)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Massachusetts Institute of Technology, Cambridge, MA, USA.

Yiming Yang (Y)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-0386-9428

Åsa Segerstolpe (Å)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Domenic Abbondanza (D)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-7202-0225

Stephen J Fleming (SJ)

Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-1885-4405

Ayshwarya Subramanian (A)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Daniel T Montoro (DT)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Karthik A Jagadeesh (KA)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Kushal K Dey (KK)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Pritha Sen (P)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Michal Slyper (M)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Yered H Pita-Juárez (YH)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard Medical School Initiative for RNA Medicine, Boston, MA, USA.
Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Devan Phillips (D)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jana Biermann (J)

Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Columbia Center for Translational Immunology, New York, NY, USA.
ORCID: 0000-0002-8907-4633

Zohar Bloom-Ackermann (Z)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nikolaos Barkas (N)

Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-4675-0718

Andrea Ganna (A)

Institute for Molecular Medicine Finland, Helsinki, Finland.
Analytical & Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

James Gomez (J)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Johannes C Melms (JC)

Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Columbia Center for Translational Immunology, New York, NY, USA.
ORCID: 0000-0002-5410-6586

Igor Katsyv (I)

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.

Erica Normandin (E)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.

Pourya Naderi (P)

Harvard Medical School, Boston, MA, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard Medical School Initiative for RNA Medicine, Boston, MA, USA.

Yury V Popov (YV)

Harvard Medical School, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Siddharth S Raju (SS)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Sebastian Niezen (S)

Harvard Medical School, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
ORCID: 0000-0002-9297-8828

Linus T-Y Tsai (LT)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, Boston, MA, USA.

Katherine J Siddle (KJ)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Malika Sud (M)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Victoria M Tran (VM)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Shamsudheen K Vellarikkal (SK)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Yiping Wang (Y)

Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Columbia Center for Translational Immunology, New York, NY, USA.

Liat Amir-Zilberstein (L)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Deepak S Atri (DS)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-8139-5419

Joseph Beechem (J)

NanoString Technologies Inc, Seattle, WA, USA.

Olga R Brook (OR)

Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
ORCID: 0000-0002-7074-8909

Jonathan Chen (J)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Prajan Divakar (P)

NanoString Technologies Inc, Seattle, WA, USA.

Phylicia Dorceus (P)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jesse M Engreitz (JM)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Genetics and BASE Initiative, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0002-5754-1719

Adam Essene (A)

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, Boston, MA, USA.

Donna M Fitzgerald (DM)

Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Robin Fropf (R)

NanoString Technologies Inc, Seattle, WA, USA.

Steven Gazal (S)

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Joshua Gould (J)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0001-9581-5461

John Grzyb (J)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Tyler Harvey (T)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jonathan Hecht (J)

Harvard Medical School, Boston, MA, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Tyler Hether (T)

NanoString Technologies Inc, Seattle, WA, USA.

Judit Jané-Valbuena (J)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Michael Leney-Greene (M)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Hui Ma (H)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Cristin McCabe (C)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Daniel E McLoughlin (DE)

Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Eric M Miller (EM)

NanoString Technologies Inc, Seattle, WA, USA.
ORCID: 0000-0002-3243-4968

Christoph Muus (C)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.

Mari Niemi (M)

Institute for Molecular Medicine Finland, Helsinki, Finland.

Robert Padera (R)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.
Department of Pathology, Harvard Medical School, Boston, MA, USA.

Liuliu Pan (L)

NanoString Technologies Inc, Seattle, WA, USA.

Deepti Pant (D)

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, Boston, MA, USA.

Carmel Pe'er (C)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jenna Pfiffner-Borges (J)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Christopher J Pinto (CJ)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Jacob Plaisted (J)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Jason Reeves (J)

NanoString Technologies Inc, Seattle, WA, USA.

Marty Ross (M)

NanoString Technologies Inc, Seattle, WA, USA.

Melissa Rudy (M)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Erroll H Rueckert (EH)

NanoString Technologies Inc, Seattle, WA, USA.

Michelle Siciliano (M)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Alexander Sturm (A)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Ellen Todres (E)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Avinash Waghray (A)

Harvard Stem Cell Institute, Cambridge, MA, USA.
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.

Sarah Warren (S)

NanoString Technologies Inc, Seattle, WA, USA.

Shuting Zhang (S)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Daniel R Zollinger (DR)

NanoString Technologies Inc, Seattle, WA, USA.

Lisa Cosimi (L)

Infectious Diseases Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Rajat M Gupta (RM)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Nir Hacohen (N)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-2349-2656

Hanina Hibshoosh (H)

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.

Winston Hide (W)

Harvard Medical School, Boston, MA, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard Medical School Initiative for RNA Medicine, Boston, MA, USA.
Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Alkes L Price (AL)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
ORCID: 0000-0002-2971-7975

Jayaraj Rajagopal (J)

Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Purushothama Rao Tata (PR)

Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
ORCID: 0000-0003-4837-0337

Stefan Riedel (S)

Harvard Medical School, Boston, MA, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
ORCID: 0000-0002-0573-4957

Gyongyi Szabo (G)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Timothy L Tickle (TL)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Patrick T Ellinor (PT)

Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Deborah Hung (D)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Genetics, Harvard Medical School, Boston, MA, USA.
Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.

Pardis C Sabeti (PC)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.

Richard Novak (R)

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
ORCID: 0000-0003-0485-4284

Robert Rogers (R)

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Massachusetts General Hospital, Boston, MA, USA.

Donald E Ingber (DE)

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-4319-6520

Z Gordon Jiang (ZG)

Harvard Medical School, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Dejan Juric (D)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0003-2983-7704

Mehrtash Babadi (M)

Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Samouil L Farhi (SL)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0003-1359-4568

Benjamin Izar (B)

Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
Columbia Center for Translational Immunology, New York, NY, USA.
Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
Program for Mathematical Genomics, Columbia University Irving Medical Center, New York, NY, USA.
ORCID: 0000-0003-2379-6702

James R Stone (JR)

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Ioannis S Vlachos (IS)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. ivlachos@bidmc.harvard.edu.
Harvard Medical School, Boston, MA, USA. ivlachos@bidmc.harvard.edu.
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA. ivlachos@bidmc.harvard.edu.
Harvard Medical School Initiative for RNA Medicine, Boston, MA, USA. ivlachos@bidmc.harvard.edu.
Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA. ivlachos@bidmc.harvard.edu.
ORCID: 0000-0002-8849-808X

Isaac H Solomon (IH)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
ORCID: 0000-0003-3432-0902

Orr Ashenberg (O)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Caroline B M Porter (CBM)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Bo Li (B)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-0668-1620

Alex K Shalek (AK)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.
Program in Health Sciences & Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA, USA. shalek@mit.edu.
Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. shalek@mit.edu.
Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA. shalek@mit.edu.
Harvard Medical School, Boston, MA, USA. shalek@mit.edu.
Harvard Stem Cell Institute, Cambridge, MA, USA. shalek@mit.edu.
Program in Computational & Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.
Program in Immunology, Harvard Medical School, Boston, MA, USA. shalek@mit.edu.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.
ORCID: 0000-0001-5670-8778

Alexandra-Chloé Villani (AC)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. avillani@mgh.harvard.edu.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. avillani@mgh.harvard.edu.
Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. avillani@mgh.harvard.edu.
Department of Medicine, Harvard Medical School, Boston, MA, USA. avillani@mgh.harvard.edu.
ORCID: 0000-0001-7461-0408

Orit Rozenblatt-Rosen (O)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. orit.r.rosen@gmail.com.
Genentech, South San Francisco, CA, USA. orit.r.rosen@gmail.com.
ORCID: 0000-0001-6313-3570

Aviv Regev (A)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.
Howard Hughes Medical Institute, Chevy Chase, MD, USA. aviv.regev.sc@gmail.com.
Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.
ORCID: 0000-0003-3293-3158

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