Molecular Characterization of Closely Related H6N2 Avian Influenza Viruses Isolated from Turkey, Egypt, and Uganda.
avian influenza virus
migratory birds
molecular markers
reassortment
waterfowl
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
02 04 2021
02 04 2021
Historique:
received:
27
02
2021
revised:
28
03
2021
accepted:
30
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Genetic analysis of circulating avian influenza viruses (AIVs) in wild birds at different geographical regions during the same period could improve our knowledge about virus transmission dynamics in natural hosts, virus evolution as well as zoonotic potential. Here, we report the genetic and molecular characterization of H6N2 influenza viruses isolated from migratory birds in Turkey, Egypt, and Uganda during 2017-2018. The Egyptian and Turkish isolates were genetically closer to each other than they were to the virus isolated from Uganda. Our results also suggest that multiple reassortment events were involved in the genesis of the isolated viruses. All viruses contained molecular markers previously associated with increased replication and/or pathogenicity in mammals. The results of this study indicate that H6N2 viruses carried by migratory birds on the West Asian/East African and Mediterranean/Black Sea flyways have the potential to transmit to mammals including humans. Additionally, adaptation markers in these viruses indicate the potential risk for poultry, which also increases the possibility of human exposure to these viruses.
Identifiants
pubmed: 33918166
pii: v13040607
doi: 10.3390/v13040607
pmc: PMC8065897
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Références
Front Cell Infect Microbiol. 2018 Nov 23;8:414
pubmed: 30533399
J Virol. 2005 Feb;79(4):2191-8
pubmed: 15681421
Microbes Infect. 2017 Dec;19(12):655-660
pubmed: 28951329
Vet Res. 2017 Feb 6;48(1):7
pubmed: 28166830
J Virol. 2000 Jul;74(14):6309-15
pubmed: 10864640
J Virol. 2006 Nov;80(22):11115-23
pubmed: 16971424
J Virol. 2011 Jan;85(2):652-62
pubmed: 21084483
J Gen Virol. 2012 Mar;93(Pt 3):531-540
pubmed: 22090209
Mol Biol Evol. 2013 Dec;30(12):2725-9
pubmed: 24132122
Arch Virol. 2001 Dec;146(12):2275-89
pubmed: 11811679
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21312-6
pubmed: 19995968
J Virol. 2008 Nov;82(21):10854-63
pubmed: 18715930
J Virol. 2011 Dec;85(23):12324-33
pubmed: 21937639
Nature. 2009 Jun 25;459(7250):1122-5
pubmed: 19516283
PLoS One. 2012;7(6):e38067
pubmed: 22675507
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Front Microbiol. 2019 Mar 06;10:432
pubmed: 30894843
Virus Genes. 2019 Dec;55(6):739-768
pubmed: 31428925
J Mol Evol. 1985;22(2):160-74
pubmed: 3934395
PLoS Pathog. 2009 Dec;5(12):e1000709
pubmed: 20041223
Lancet Respir Med. 2013 Dec;1(10):771-8
pubmed: 24461756
Clin Infect Dis. 2007 Jul 1;45(1):4-9
pubmed: 17554693
PLoS Pathog. 2007 Oct 5;3(10):1414-21
pubmed: 17922571
J Virol. 2018 Apr 27;92(10):
pubmed: 29491160
J Virol. 2014 Mar;88(6):3127-34
pubmed: 24371069
J Gen Virol. 2011 Jun;92(Pt 6):1435-1444
pubmed: 21367983
Emerg Infect Dis. 2015 Jul;21(7):1267-9
pubmed: 26079934
PLoS One. 2012;7(7):e41609
pubmed: 22848544
J Virol. 2012 Jun;86(11):6075-83
pubmed: 22438558
Emerg Infect Dis. 2006 Jan;12(1):15-22
pubmed: 16494711
J Virol. 2011 Feb;85(4):1834-46
pubmed: 21123376
J Virol. 2013 May;87(9):4861-71
pubmed: 23408626
Virology. 2009 Feb 5;384(1):28-32
pubmed: 19117585
Comp Immunol Microbiol Infect Dis. 2013 Sep;36(5):521-36
pubmed: 23891310
J Virol. 2008 Feb;82(3):1146-54
pubmed: 18032512
Cell Host Microbe. 2007 Oct 11;2(4):240-9
pubmed: 18005742
Virus Res. 2009 Sep;144(1-2):123-9
pubmed: 19393699
J Virol. 1989 Nov;63(11):4603-8
pubmed: 2795713
J Virol. 2007 Aug;81(16):8515-24
pubmed: 17553873
Clin Infect Dis. 2013 Nov;57(9):1367-8
pubmed: 23881153
Vet Microbiol. 2019 Aug;235:21-24
pubmed: 31282375
Infect Genet Evol. 2018 Jul;61:20-23
pubmed: 29530659
J Exp Med. 2006 Mar 20;203(3):689-97
pubmed: 16533883
Virology. 1978 Jun 1;87(1):13-20
pubmed: 664248
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18590-5
pubmed: 16339318
Ecohealth. 2011 Mar;8(1):4-13
pubmed: 21516374
Emerg Microbes Infect. 2019;8(1):650-661
pubmed: 31014196
Infect Genet Evol. 2016 Jan;37:8-13
pubmed: 26477933