Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach.
CKD
cell-free therapeutic
cellular communication
exosomes
extracellular vesicles
mesenchymal stem cells
regeneration
renal fibrosis
renoprotection
therapeutic agents
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Apr 2021
09 Apr 2021
Historique:
received:
12
03
2021
revised:
06
04
2021
accepted:
07
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
26
5
2021
Statut:
epublish
Résumé
Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases.
Identifiants
pubmed: 33918699
pii: ijms22083887
doi: 10.3390/ijms22083887
pmc: PMC8069044
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : CP19/00027
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 451-03-9/2021-14/200019
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