Role of Decorin in Posterior Capsule Opacification and Eye Lens Development.
Aging
/ pathology
Animals
Aqueous Humor
/ drug effects
Capsule Opacification
/ metabolism
Cataract
/ genetics
Decorin
/ genetics
Disease Models, Animal
Down-Regulation
/ genetics
Epithelial Cells
/ metabolism
Epithelial-Mesenchymal Transition
/ drug effects
Fibroblast Growth Factors
/ pharmacology
Fibroblasts
/ drug effects
Gene Expression Profiling
Gene Ontology
Humans
Lens, Crystalline
/ embryology
Mice, Inbred C57BL
Mice, Transgenic
Rats, Sprague-Dawley
Severity of Illness Index
Transforming Growth Factor beta2
/ pharmacology
Tropomyosin
/ metabolism
Up-Regulation
/ genetics
Wound Healing
/ drug effects
Decorin
epithelial-mesenchymal transition
lens development
posterior capsule opacification
wound healing
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
09 04 2021
09 04 2021
Historique:
received:
25
02
2021
revised:
06
04
2021
accepted:
08
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Decorin (DCN) is involved in a variety of physiological and pathological processes. Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) has been proposed as a major cause for the development of posterior capsule opacification (PCO) after cataract surgery. We investigated the plausible target gene(s) that suppress PCO. The expression of
Identifiants
pubmed: 33918979
pii: cells10040863
doi: 10.3390/cells10040863
pmc: PMC8070370
pii:
doi:
Substances chimiques
Decorin
0
Tpm1 protein, mouse
0
Transforming Growth Factor beta2
0
Tropomyosin
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY024589
Pays : United States
Organisme : NEI NIH HHS
ID : EY024589
Pays : United States
Organisme : Japan Society for the Promotion of Science
ID : C 23592588
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