Perinatal Exposure to Phthalates: From Endocrine to Neurodevelopment Effects.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
14 Apr 2021
Historique:
received: 01 02 2021
revised: 06 04 2021
accepted: 10 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 13 5 2021
Statut: epublish

Résumé

Phthalates, as other endocrine disrupting chemicals (EDCs), may alter the homeostasis and the action of hormones and signaling molecules, causing adverse health outcomes. This is true especially for infants, who are both more exposed and sensitive to their effects. Phthalates are particularly harmful when the exposure occurs during certain critical temporal windows of the development, such as the prenatal and the early postnatal phases. Phthalates may also interfere with the neuroendocrine systems (e.g., thyroid hormone signaling or metabolism), causing disruption of neuronal differentiation and maturation, increasing the risk of behavioral and cognitive disorders (ADHD and autistic behaviors, reduced mental, psychomotor, and IQ development, and emotional problems). Despite more studies being needed to better understand the role of these substances, plenty of evidence suggests the impact of phthalates on the neuroendocrine system development and function. This review aims to update the knowledge on the neuroendocrine consequences of neonatal and perinatal exposure to phthalates.

Identifiants

pubmed: 33920043
pii: ijms22084063
doi: 10.3390/ijms22084063
pmc: PMC8070995
pii:
doi:

Substances chimiques

Endocrine Disruptors 0
Environmental Pollutants 0
Phthalic Acids 0
phthalic acid 6O7F7IX66E

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Références

J Toxicol Environ Health A. 2002 Mar;65(5-6):447-59
pubmed: 11936224
Mol Biol Rep. 2014 Mar;41(3):1227-35
pubmed: 24390239
Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180123
pubmed: 30966889
Environ Int. 2019 Nov;132:105102
pubmed: 31491609
Environ Health Perspect. 2000 Jun;108 Suppl 3:511-33
pubmed: 10852851
J Clin Endocrinol Metab. 2017 Jun 1;102(6):1870-1878
pubmed: 28324030
J Dev Orig Health Dis. 2017 Jun;8(3):273-283
pubmed: 28196555
Mol Nutr Food Res. 2007 Jul;51(7):899-911
pubmed: 17604388
Aquat Toxicol. 2020 May;222:105469
pubmed: 32179334
Chemosphere. 2018 Sep;206:759-765
pubmed: 29793068
Neurotoxicology. 2015 May;48:21-34
pubmed: 25749100
Environ Res. 2018 Apr;162:261-270
pubmed: 29367177
J Neuroendocrinol. 2004 Oct;16(10):809-18
pubmed: 15500540
Sci Total Environ. 2019 Sep 15;683:109-115
pubmed: 31129321
Birth Defects Res. 2020 Oct;112(17):1308-1325
pubmed: 32476245
Mol Cell Endocrinol. 2014 Dec;398(1-2):4-12
pubmed: 25088466
Environ Pollut. 2021 Feb 15;271:116380
pubmed: 33387779
Toxicol Ind Health. 2010 Aug;26(7):407-16
pubmed: 20504828
J Expo Sci Environ Epidemiol. 2017 Nov;27(6):582-590
pubmed: 27703149
Neurotoxicology. 2009 Jul;30(4):522-8
pubmed: 19375452
Neurotoxicology. 2020 Sep;80:20-28
pubmed: 32479765
Environ Res. 2018 Feb;161:505-511
pubmed: 29223775
Sci Total Environ. 2017 Dec 31;607-608:881-887
pubmed: 28711850
J Pharm Biomed Anal. 2018 Jan 30;148:6-16
pubmed: 28946042
EFSA J. 2019 Dec 11;17(12):e05838
pubmed: 32626195
Bull Environ Contam Toxicol. 2004 Jun;72(6):1226-31
pubmed: 15362453
Environ Int. 2009 Feb;35(2):236-9
pubmed: 18684505
J Expo Sci Environ Epidemiol. 2020 Jan;30(1):56-69
pubmed: 31481681
Gynecol Endocrinol. 2018 Nov;34(11):1001-1004
pubmed: 29842821
Environ Int. 2019 Nov;132:105061
pubmed: 31400598
J Int Neuropsychol Soc. 2001 Sep;7(6):734-44
pubmed: 11575595
Int J Toxicol. 2010 Mar-Apr;29(2):193-200
pubmed: 20335514
Environ Int. 2019 Nov;132:105103
pubmed: 31470218
J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):204-15
pubmed: 21899826
Best Pract Res Clin Endocrinol Metab. 2020 Dec 17;:101478
pubmed: 33608224
J Dev Orig Health Dis. 2017 Oct;8(5):513-519
pubmed: 28889823
Mol Psychiatry. 2011 Nov;16(11):1147-54
pubmed: 20856250
JAMA. 2009 Sep 9;302(10):1084-91
pubmed: 19738093
Int J Endocrinol. 2013;2013:862739
pubmed: 23762055
J Endocrinol. 2019 Jul 1;242(1):T105-T119
pubmed: 31091503
Toxicol Sci. 2009 Aug;110(2):411-25
pubmed: 19482887
Curr Opin Pediatr. 2020 Aug;32(4):554-559
pubmed: 32692053
Placenta. 2007 Apr;28 Suppl A:S33-40
pubmed: 17140657
Int J Hyg Environ Health. 2007 Jan;210(1):9-19
pubmed: 17182279
Environ Health Perspect. 2015 Mar;123(3):210-6
pubmed: 25402001
Epigenomics. 2018 Jul;10(7):1011-1026
pubmed: 29957030
PLoS One. 2013;8(1):e55387
pubmed: 23359474
Arch Toxicol. 2004 Mar;78(3):123-30
pubmed: 14576974
Environ Sci Technol. 2019 Sep 17;53(18):10813-10826
pubmed: 31424210
Sci Total Environ. 2013 Aug 1;458-460:451-8
pubmed: 23688967
Biol Reprod. 2013 May 02;88(5):112
pubmed: 23536373
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jun 5;805(1):49-56
pubmed: 15113539
Environ Sci Technol. 2016 Apr 19;50(8):4350-7
pubmed: 27007912
Parkinsonism Relat Disord. 2002 Mar;8(4):235-41
pubmed: 12039417
J Dev Orig Health Dis. 2013 Aug;4(4):300-6
pubmed: 24349678
Nat Rev Endocrinol. 2017 Mar;13(3):161-173
pubmed: 27857130
Environ Health Perspect. 2000 Jun;108 Suppl 3:545-53
pubmed: 10852853
Int J Mol Sci. 2020 Mar 18;21(6):
pubmed: 32197344
Environ Res. 2019 Jun;173:342-348
pubmed: 30953948
J Endocrinol. 2014 Oct;223(1):47-66
pubmed: 25232145
Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:293-299
pubmed: 31400564
Early Hum Dev. 2006 Apr;82(4):257-66
pubmed: 16360292
Environ Int. 2020 Oct;143:105894
pubmed: 32679391
BJOG. 2009 Apr;116(5):637-42
pubmed: 19298438
Regul Toxicol Pharmacol. 2015 Oct;73(1):85-92
pubmed: 26123074
Int J Genomics. 2019 Jan 14;2019:2085496
pubmed: 30733955
Reprod Toxicol. 2019 Aug;87:146-155
pubmed: 31170452
Cell Commun Signal. 2013 May 17;11(1):34
pubmed: 23683503
Environ Health Perspect. 2005 Sep;113(9):1230-3
pubmed: 16140633
J Epidemiol Community Health. 1989 Sep;43(3):237-40
pubmed: 2607302
Environ Res. 2016 Nov;151:777-782
pubmed: 27567446
Environ Health. 2019 Aug 30;18(1):80
pubmed: 31470855
World J Biol Chem. 2017 May 26;8(2):108-119
pubmed: 28588754
Metabolism. 2016 Jun;65(6):874-82
pubmed: 27173466
Environ Int. 2018 Nov;120:572-583
pubmed: 30195175
Int J Hyg Environ Health. 2020 Aug;229:113548
pubmed: 32659708
Anal Bioanal Chem. 2005 Jun;382(4):1084-92
pubmed: 15933851
Environ Health Perspect. 2006 Aug;114(8):1158-61
pubmed: 16882519
Front Endocrinol (Lausanne). 2015 Feb 02;6:8
pubmed: 25699018
Paediatr Perinat Epidemiol. 2016 Mar;30(2):105-14
pubmed: 26576028
J Dev Orig Health Dis. 2015 Apr;6(2):96-104
pubmed: 25708304

Auteurs

Laura Lucaccioni (L)

Pediatric Unit, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Viola Trevisani (V)

Department of Medical and Surgical Sciences of the Mothers, Post Graduate School of Paediatrics, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Erica Passini (E)

Department of Medical and Surgical Sciences of the Mothers, Post Graduate School of Paediatrics, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Beatrice Righi (B)

Pediatric Unit, Ramazzini Hospital, 41012 Carpi, Italy.

Carlotta Plessi (C)

Department of Medical and Surgical Sciences and NeuroSciences, Post Graduate School of Pediatric Surgery, University of Siena, 53100 Siena, Italy.

Barbara Predieri (B)

Pediatric Unit, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Lorenzo Iughetti (L)

Pediatric Unit, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Department of Medical and Surgical Sciences of the Mothers, Post Graduate School of Paediatrics, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.

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