Citric Acid Cycle Metabolites Predict Infarct Size in

Animals Biomarkers / blood Citric Acid Cycle Coronary Occlusion / metabolism Dicarboxylic Acids / blood Enzyme Inhibitors / pharmacology Heart / drug effects Ischemic Preconditioning / methods Myocardial Infarction / metabolism Myocardium / metabolism Succinate Dehydrogenase / antagonists & inhibitors Swine
ischemia-reperfusion malonate myocardial infarction remote ischemic conditioning succinate dehydrogenase

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Apr 2021
Historique:
received: 03 03 2021
revised: 13 04 2021
accepted: 14 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 13 5 2021
Statut: epublish

Résumé

Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. We investigated whether protection by SDH inhibition is additive to that of remote ischemic perconditioning (RIC) in

Identifiants

DOI: 10.3390/ijms22084151 PMID: 33923786 PMC: PMC8072915
pubmed: 33923786
pii: ijms22084151
doi: 10.3390/ijms22084151
pmc: PMC8072915
pii:
doi:

Substances chimiques

Biomarkers 0
Dicarboxylic Acids 0
Enzyme Inhibitors 0
Succinate Dehydrogenase EC 1.3.99.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI17/01397
Organisme : Instituto de Salud Carlos III
ID : CIBERCV
Organisme : Sociedad Española de Cardiología
ID : Proyectos de la FEC para Investigación Básica en Cardiología 2018, Sociedad Española de Cardiología
Organisme : European Regional Development Fund
ID : ERDF-FEDER

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Auteurs

Marta Consegal (M)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
ORCID: 0000-0002-9201-9117

Norberto Núñez (N)

Unit of High Technology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

Ignasi Barba (I)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Faculty of Medicine, University of Vic-Central University of Catalonia (UVicUCC), Can Baumann. Ctra. de Roda, 70, 08500 Vic, Spain.
ORCID: 0000-0001-9886-3776

Begoña Benito (B)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Marisol Ruiz-Meana (M)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Javier Inserte (J)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
ORCID: 0000-0002-4736-5010

Ignacio Ferreira-González (I)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Antonio Rodríguez-Sinovas (A)

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
ORCID: 0000-0003-2930-8773

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Cycle citrique › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Occlusion coronarienne › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Système cardiovasculaire › Coeur › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Techniques d'investigation › Préconditionnement ischémique › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Ferrosulfoprotéines › Complexe II de la chaîne respiratoire › Succinate Dehydrogenase › Citric Acid Cycle Metabolites Predict Infarct Size in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Citric Acid Cycle Metabolites Predict Infarct Size in