Vasoactive Effects of Acute Ergot Exposure in Sheep.
Adrenergic alpha-1 Receptor Antagonists
/ pharmacology
Animals
Arteries
/ drug effects
Ergot Alkaloids
/ toxicity
Ergotism
/ metabolism
Female
Hindlimb
/ blood supply
Muscle, Smooth, Vascular
/ drug effects
Prazosin
/ analogs & derivatives
Receptors, Adrenergic, alpha-1
/ metabolism
Sheep, Domestic
Signal Transduction
Vasoconstriction
/ drug effects
Vasoconstrictor Agents
/ pharmacology
acute ergot exposure
adrenergic receptors
ergot toxicity
sheep
vasoconstriction
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
received:
14
02
2021
revised:
29
03
2021
accepted:
02
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
30
6
2021
Statut:
epublish
Résumé
Ergotism is a common and increasing problem in Saskatchewan's livestock. Chronic exposure to low concentrations of ergot alkaloids is known to cause severe arterial vasoconstriction and gangrene through the activation of adrenergic and serotonergic receptors on vascular smooth muscles. The acute vascular effects of a single oral dose with high-level exposure to ergot alkaloids remain unknown and are examined in this study. This study had two main objectives; the first was to evaluate the role of α
Identifiants
pubmed: 33924041
pii: toxins13040291
doi: 10.3390/toxins13040291
pmc: PMC8072561
pii:
doi:
Substances chimiques
Adrenergic alpha-1 Receptor Antagonists
0
Ergot Alkaloids
0
Receptors, Adrenergic, alpha-1
0
Vasoconstrictor Agents
0
Terazosin
8L5014XET7
Prazosin
XM03YJ541D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Saskatchewan Ministry of Agriculture-Agriculture Development Fund (ADF)
ID : 20140186
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