Smaller volume and altered functional connectivity of the amygdala in patients with lifelong premature ejaculation.
Amygdala
Functional connectivity
Gray matter volume
Neuroimaging
Premature ejaculation
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
29
12
2020
accepted:
19
04
2021
revised:
04
04
2021
pubmed:
1
5
2021
medline:
21
10
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
To analyze the abnormal amygdala structure and function in lifelong premature ejaculation (PE) patients compared with healthy controls (HCs). Forty-four lifelong PE patients and thirty-one HCs were enrolled in this study. Each subject was diagnosed with PE using a Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculation latency time (IELT) score. Based on t-tests and Pearson correlation analysis, the voxel-based morphometry and functional connectivity (FC) analyses were applied to evaluate brain structural and functional changes by using T1-weighted and resting-state functional magnetic resonance imaging scans. Lifelong PE patients had decreased gray matter volume in the bilateral amygdala and increased FC between the amygdala and precuneus, posterior cingulate cortex (PCC), and middle temporal cortex (MTC), as well as decreased FC between the amygdala and precentral gyrus, insula, and inferior frontal gyrus. Moreover, significantly negative correlations between the IELT score and the mean z-score from amygdala-MTC (r = -0.49) and amygdala-PCC (r = -0.48) FC were found in lifelong PE patients. Our study investigated the abnormal amygdala-related structure and connectivity patterns in PE patients, which might provide novel perspective for understanding the crucial role of the amygdala in the neural mechanism of PE. • As one of the most common diseases in men, PE may be related to abnormal brain mechanisms. • Functional and structural magnetic resonance imaging used to explore amygdala abnormalities in PE patients. • The correlation between clinical scores and functional connectivity was used to assess the reasonability of the results.
Identifiants
pubmed: 33928418
doi: 10.1007/s00330-021-08002-9
pii: 10.1007/s00330-021-08002-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8429-8437Subventions
Organisme : National Natural Science Foundation of China
ID : 81771918
Organisme : National Natural Science Foundation of China
ID : 61971425
Organisme : National Natural Science Foundation of China
ID : 62001370
Organisme : Natural Science Foundation of Shaanxi Province
ID : 2020JM-197
Organisme : Postdoctoral Research Foundation of China
ID : 2019M650985
Organisme : Shaanxi Provincial Science and Technology Department
ID : 2018SF/091
Informations de copyright
© 2021. European Society of Radiology.
Références
Chung E, Gilbert B, Perera M, Roberts MJ (2015) Premature ejaculation: a clinical review for the general physician. Aust Fam Physician 44:737–743
pubmed: 26484490
Althof SE, McMahon CG, Waldinger MD et al (2014) An update of the International Society of Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2:60–90
pubmed: 25356302
pmcid: 4184677
Stoleru S, Fonteille V, Cornelis C, Joyal C, Moulier V (2012) Functional neuroimaging studies of sexual arousal and orgasm in healthy men and women: a review and meta-analysis. Neurosci Biobehav Rev 36:1481–1509
pubmed: 22465619
Holstege G, Georgiadis JR, Paans AMJ, Meiners LC, van der Graaf FHCE, Reinders AATS (2003) Brain activation during human male ejaculation. J Neurosci 23:9185–9193
pubmed: 14534252
pmcid: 6740826
Gao M, Feng NN, Wu JY et al (2020) Altered functional connectivity of hypothalamus in lifelong premature ejaculation patients. J Magn Reson Imaging 52:778–784
pubmed: 32068927
Lu JM, Zhang X, Wang HT et al (2018) Short- and long-range synergism disorders in lifelong premature ejaculation evaluated using the functional connectivity density and network property. Neuroimage Clin 19:607–615
pubmed: 29984168
pmcid: 6029581
Redoute J, Stoleru S, Gregoire MC et al (2000) Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 11:162–177
pubmed: 11098795
pmcid: 6871964
Karama S, Lecours AR, Leroux J et al (2002) Areas of brain activation in males and females. During viewing of erotic film excerpts. Hum Brain Mapp 16:1–13
pubmed: 11870922
pmcid: 6871831
Hamann S, Herman RA, Nolan CL, Wallen K (2004) Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci 7:411–416
pubmed: 15004563
Althof SE, Abdo CHN, Dean J et al (2010) International Society for Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 7:2947–2969
pubmed: 21050394
Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM (1999) Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 11:319–326
pubmed: 10637462
Ossewaarde L, Hermans EJ, van Wingen GA et al (2010) Neural mechanisms underlying changes in stress-sensitivity across the menstrual cycle. Psychoneuroendocrinology 35:47–55
pubmed: 19758762
Yang L, Dun W, Li K et al (2019) Altered amygdalar volume and functional connectivity in primary dysmenorrhoea during the menstrual cycle. Eur J Pain 23:994–1005
pubmed: 30664322
Yan CG, Wang XD, Zuo XN, Zang YF (2016) DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging. Neuroinformatics 14:339–351
pubmed: 27075850
Song XW, Dong ZY, Long XY et al (2011) REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One 6:e25031
pubmed: 21949842
pmcid: 3176805
Liao XH, Xia MR, Xu T et al (2013) Functional brain hubs and their test-retest reliability: a multiband resting-state functional MRI study. Neuroimage 83:969–982
pubmed: 23899725
Fox MD, Zhang D, Snyder AZ, Raichle ME (2009) The global signal and observed anticorrelated resting state brain networks. J Neurophysiol 101:3270–3283
pubmed: 19339462
pmcid: 2694109
Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA (2009) The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44:893–905
pubmed: 18976716
Weissenbacher A, Kasess C, Gerstl F, Lanzenberger R, Moser E, Windischberger C (2009) Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies. Neuroimage 47:1408–1416
pubmed: 19442749
Hamilton JP, Siemer M, Gotlib IH (2008) Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Mol Psychiatry 13:993–1000
pubmed: 18504424
pmcid: 2739676
Deng D, Pang Y, Duan G et al (2018) Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome. Eur Radiol 28:1900–1908
pubmed: 29260367
Wu X, Wu Y, Geng Z et al (2020) Asymmetric Differences in the gray matter volume and functional connections of the amygdala are associated with clinical manifestations of Alzheimer’s disease. Front Neurosci 14:602
pubmed: 32670008
pmcid: 7332559
Arnow BA, Desmond JE, Banner LL et al (2002) Brain activation and sexual arousal in healthy, heterosexual males. Brain 125:1014–1023
pubmed: 11960892
Moulier V, Mouras H, Pelegrini-Issac M et al (2006) Neuroanatomical correlates of penile erection evoked by photographic stimuli in human males. Neuroimage 33:689–699
pubmed: 16962339
Ferretti A, Caulo M, Del Gratta C et al (2005) Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. Neuroimage 26:1086–1096
pubmed: 15961048
Mouras H, Stoleru S, Moulier V et al (2008) Activation of mirror-neuron system by erotic video clips predicts degree of induced erection: an fMRI study. Neuroimage 42:1142–1150
pubmed: 18598769
Zhang B, Lu JM, Xia JD et al (2017) Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation. Sci Rep 7:460
pubmed: 28352072
pmcid: 5428429
Xu ZL, Yang XJ, Gao M et al (2019) Abnormal resting-state functional connectivity in the whole brain in lifelong premature ejaculation patients based on machine learning approach. Front Neurosci 13:448
pubmed: 31139043
pmcid: 6519512
Li R, Utevsky AV, Huettel SA et al (2019) Developmental maturation of the precuneus as a functional core of the default mode network. J Cogn Neurosci 31:1506–1519
pubmed: 31112473
Whitfield-Gabrieli S, Ford JM (2012) Default mode network activity and connectivity in psychopathology. Annu Rev Clin Psychol 8:49–76
pubmed: 22224834
Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL (2001) A default mode of brain function. Proc Natl Acad Sci U S A 98:676–682
pubmed: 11209064
pmcid: 14647
Buckner RL, Vincent JL (2007) Unrest at rest: default activity and spontaneous network correlations. Neuroimage 37:1091–1096
pubmed: 17368915
D’Argembeau A, Collette F, Van der Linden M et al (2005) Self-referential reflective activity and its relationship with rest: a PET study. Neuroimage 25:616–624
pubmed: 15784441
Cera N, Di Pierro ED, Sepede G et al (2012) The role of left superior parietal lobe in male sexual behavior: dynamics of distinct components revealed by fMRI. J Sex Med 9:1602–1612
pubmed: 22510246
Guo F, Xi YB, Gao M et al (2018) Alterations in cortical thickness in nonmedicated premature ejaculation patients: a morphometric MRI study. J Magn Reson Imaging 47:656–662
pubmed: 28736888
Lundstrom BN, Ingvar M, Petersson KM (2005) The role of precuneus and left inferior frontal cortex during source memory episodic retrieval. Neuroimage 27:824–834
pubmed: 15982902
Maddock RF, Garrett AS, Buonocore MH (2001) Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience 104:667–676
pubmed: 11440800
Hayden BY, Nair AC, Mccoy AN, Platt ML (2008) Posterior cingulate cortex mediates outcome-contingent allocation of behavior. Neuron 60:19–25
pubmed: 18940585
pmcid: 2575690
Maddock RJ, Garrett AS, Buonocore MH (2003) Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Hum Brain Mapp 18:30–41
pubmed: 12454910
Rupp HA, Wallen K (2008) Sex differences in response to visual sexual stimuli: a review. Arch Sex Behav 37:206–218
pubmed: 17668311
Yang XJ, Gao M, Zhang L et al (2018) Central neural correlates during inhibitory control in lifelong premature ejaculation patients. Front Hum Neurosci 12:206
pubmed: 29872385
pmcid: 5972200
Mouras H, Stoleru S, Bittoun J et al (2003) Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study. Neuroimage 20:855–869
pubmed: 14568457
Hyun JS, Kam SC, Kwon OY (2008) Changes of cerebral current source by audiovisual erotic stimuli in premature ejaculation patients. J Sex Med 5:1474–1481
pubmed: 18194183
Braun CM, Dumont M, Duval J, Hamel I, Godbout L (2003) Opposed left and right brain hemisphere contributions to sexual drive: A multiple lesion case analysis. Behav Neurol 14:55–61
pubmed: 12719639
pmcid: 5497559
Poeppl TB, Langguth B, Laird AR, Eickhoff SB (2014) The functional neuroanatomy of male psychosexual and physiosexual arousal: a quantitative meta-analysis. Hum Brain Mapp 35:1404–1421
pubmed: 23674246
Zhang TT, Tang DD, Cai HH et al (2020) Selective functional hyperconnectivity in the middle temporal gyrus subregions in lifelong premature ejaculation. J Sex Med 17:1457–1466
pubmed: 32624358