Comparing continuous subcutaneous insulin infusion and multiple daily injections in children with Type 1 diabetes in Sweden from 2011 to 2016-A longitudinal study from the Swedish National Quality Register (SWEDIABKIDS).
Adolescent
Blood Glucose
/ analysis
Child
Child, Preschool
Cross-Sectional Studies
Diabetes Mellitus, Type 1
/ blood
Drug Administration Schedule
Female
Glycated Hemoglobin
/ analysis
Glycemic Control
/ methods
History, 21st Century
Humans
Infant
Infant, Newborn
Injections, Subcutaneous
Insulin
/ administration & dosage
Insulin Infusion Systems
Longitudinal Studies
Male
Quality Assurance, Health Care
/ statistics & numerical data
Registries
Sweden
/ epidemiology
HbA1c
continuous subcutaneous insulin infusion
hypoglycemia
metabolic control
multiple daily injection
Journal
Pediatric diabetes
ISSN: 1399-5448
Titre abrégé: Pediatr Diabetes
Pays: Denmark
ID NLM: 100939345
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
18
03
2021
received:
12
12
2020
accepted:
06
04
2021
pubmed:
1
5
2021
medline:
29
1
2022
entrez:
30
4
2021
Statut:
ppublish
Résumé
This study aimed to compare metabolic control measured as hemoglobin A1c (HbA1c), the risk of severe hypoglycemia, and body composition measured as body mass index standard deviation scores (BMI-SDS) in a nationwide sample of children and adolescents with Type 1 diabetes with continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI), respectively. Longitudinal data from 2011 to 2016 were extracted from the Swedish National Quality Register (SWEDIABKIDS) with both cross-sectional (6 years) and longitudinal (4 years) comparisons. Main end points were changes in HbA1c, BMI-SDS, and incidence of severe hypoglycemia. Data were available from 35,624 patient-years (54% boys). In general, HbA1c decreased approximately 0.5% (2-5 mmol/mol) from 2011 to 2016 (p There was a small decrease in HbA1c with CSII treatment but of little clinical relevance. Overall, mean HbA1c decreased in both sexes and all age groups without increasing the episodes of severe hypoglycemia, indicating that other factors than insulin method contributed to a better metabolic control.
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Insulin
0
Types de publication
Comparative Study
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
766-775Informations de copyright
© 2021 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd.
Références
Swediabkids-Swedish national quality registry for diabetes in children and adolescents. http://www.ndr.nu/pdfs/Yearreport_Swediabkids_2018_Eng.pdf. Accessed 1/3/2021.
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
The Diabetes Control and Complications Trial Research Group. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: diabetes control and complications trial. J Pediatr. 1994;125:177-188.
Lind M, Svensson A-M, Kosiborod M, Gudbjörnsdottir S. Glycemic control and excess mortality in type 1 diabetes. N Engl J Med. 2014;371:1972-1982.
Pickup JC, Keen H, Parsons JA, Alberti KG. Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia. Br Med J. 1978;1:204-207.
Tamborlane WV, Sherwin RS, Genel M, Felig P. Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med. 1979;300:573-578.
Pickup J, Mattock M, Kerry S. Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: meta-analysis of randomised controlled trials. BMJ. 2002;324:705.
Weissberg-Benchell J, Antisdel-Lomaglio J, Seshadri R. Insulin pump therapy: a meta-analysis. Diabetes Care. 2003;26:1079-1087.
Bangstad HJ, Danne T, Deeb T, Hanas R. Insulin treatment in children and adolescents with diabetes. Pediatr Diabetes. 2009;10(Suppl 12):82-99.
Sulli N, Shashaj B. Continuous subcutaneous insulin infusion in children and adolescents with diabetes mellitus: decreased HbA1c with low risk of hypoglycemia. J Pediatr Endocrinol Metab. 2003;16:393-399.
Jeha G, Karaviti L, Anderson B, et al. Insulin pump therapy in pre-school children with type 1 diabetes mellitus improves control and decreases glucose excursion and the risks of hypoglycaemia. Diabetes Technol Ther. 2005;7:876-884.
Berghaeuser MA, Kapellen T, Heidtmann B, Haberland H, Klinkert C, Holl RW. Continuous subcutaneous insulin infusion in toddlers starting at diagnosis of type 1 diabetes mellitus. A multicenter analysis of 104 patients from 63 centres in Germany and Austria. Pediatr Diabetes. 2008;9:590-595.
Jakisch BI, Wagner VM, Heidtmann B, et al. Comparison of continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) in paediatric type 1 diabetes: a multicentre matched-pair cohort analysis over 3 years. Diabet Med. 2008;25:80-85.
Ahern JA, Boland EA, Doane R, et al. Insulin pump therapy in paediatrics: a therapeutic alternative to safely lower HbA1c levels across all age groups. Pediatr Diabetes. 2002;3:10-15.
Plotnick LP, Clark LM, Brancati FL, Erlinger T. Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes. Diabetes Care. 2003;26:1142-1146.
Skogsberg L, Fors H, Hanas R, Chaplin JE. Improved treatment satisfaction but no difference in metabolic control when using continuous subcutaneous insulin infusion vs. multiple daily injection in children at onset of type 1 diabetes mellitus. Pediatr Diabetes. 2008;9:472-479.
Brorsson AL, Viklund G, Örtqvist E, Olinder AL. Does treatment with insulin pump improve glycaemic control in children and adolescents with type 1 diabetes? A retrospective case-control study. Pediatr Diabetes. 2015;16:546-553.
Weinzimer SA, Ahern JH, Doyle EA, et al. Persistence of benefits of continuous subcutaneous insulin infusion in very young children with type 1 diabetes: a follow-up report. Paediatrics. 2004;114:1601-1605.
Kordonouri O, Hartmann R, Lauterborn R, Barnekow C, Hoeffe J, Deiss D. Age-specific advantages of continuous subcutaneous insulin infusion as compared with multiple daily injections in paediatric patients: one-year follow-up comparison by matched-pair analysis. Diabetes Care. 2006;29:133-134.
Wettermark B, Hammar N, MichaelFored C, et al. The new Swedish Prescibed drug register-opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf. 2007;16:726-735.
The Swedish Pediatric Diabetes Quality Registry SWEDIABKIDS, 2016. https://swediabkids.ndr.nu/DocumentsAnnualReport.aspx. Accessed 1/3/2021.
Lindblad B, Nordin G. External quality assessment of HbA1c and its effect on comparison between Swedish pediatric diabetes clinics. Experiences from the Swedish pediatric diabetes quality register (Swediabkids) and equalis. Clin Chem Lab Med. 2013;51(10):2045-2052.
Hoelzel W, Weykamp C, Jeppson JO, et al. IFCC reference system for measurement of hemoglobin A1c in human blood and the national standardization schemes in the United States, Japan, and Sweden: a method-comparison study. Clin Chem. 2004;50:166-174.
NGSP converter tool. https://ngsp.org/convert1.asp. Accessed 1/3/2021.
Karlberg J, Luo ZC, Albertsson-Wikland K. Body mass index reference values (mean and SD) for Swedish children. Acta Paediatr. 2002;91(3):362.
Samuelsson U, Anderzén J, Gudbjornsdottir S, Steineck I. Teenage girls with type 1 diabetes have poorer metabolic control than boys and face more complications in early adulthood. J Diabetes Complications. 2016;30:917-922.
Pankowska E, Blazik M, Dziechciarz P, Szypowska A, Szajewska H. Continuous subcutaneous insulin infusion vs. multiple daily injections in children with type 1 diabetes: a systematic review and meta-analysis of randomized control trials. Pediatr Diabetes. 2009;10:52-58.
Blair J, McKay A, Ridyard C, Thornborough K. Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation. Br Med J. 2019;365:I1226.
Shalitin S, Gil M, Nimri R, De Vries L, Gavan MY, Phillip M. Predictors of glycaemic control in patients with type 1 diabetes commencing continuous subcutaneous insulin infusion therapy. Diabet Med. 2010;27:339-347.
Pilgaard KA, Breinegaard N, Johannesen J, et al. Episodes of severe hypoglycemia is associated with a progressive increase in hemoglobin A1c in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2020;21:808-813.
Olsen B, Johannesen J, Fredheim S, Svensson J. Insulin pump treatment; increasing prevalence, and predictors for better metabolic outcome in Danish children and adolescents with type 1 diabetes. Pediatr Diabetes. 2015;16:256-262.
Mameli C, Scaramuzza AE, Ho J, Cardona-Hernandez R, Suarez-Ortega L, Zucotti GV. A 7-year follow-up retrospective, international, multicenter study of insulin pump therapy in children and adolescents with type 1 diabetes. Acta Diabetol. 2014;51(2):205-210.
Ibfelt EH, Vistisen D, Falberg Rønn P, et al. Association between glycaemic outcome and BMI in Danish children with type 1 diabetes in 2000-2018: a nationwide population-based study. Diabet Med. 2020;00:e14401.
Birkebaek NH, Kahlert J, Bjarnason R, et al. Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS. Pediatr Diabetes. 2018;19:1198-1205.
Hilgard D, Konrad K, Meusers M, et al. Comorbidity of attention deficit hyperactivity disorders and type 1 diabetes in children and adolescents: analysis based on the multicentre DPV registry. Pediatr Diabetes. 2017;18:706-713.
Tascini G, Berioli MG, Cerquiglini L, Santi E. Carbohydrate counting in children and adolescents with type 1 diabetes. Nutrients. 2018;10(1):109.
DeBoer MD, Buckingham BA, Chernavvsky D, Wadwa RP. iDCL trial research group. A randomized trial of closed-loop control in children with type 1 diabetes. N Engl J Med. 2020;383(9):836-845.