Anguillid herpesvirus 1 (AngHV) ORF95 encodes a late, structural envelope protein.
Anguillid herpesvirus
Envelope protein
Late gene
ORF95
Subcellular localization
Journal
Virus genes
ISSN: 1572-994X
Titre abrégé: Virus Genes
Pays: United States
ID NLM: 8803967
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
20
01
2021
accepted:
17
04
2021
pubmed:
1
5
2021
medline:
31
8
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Anguillid herpesvirus 1 (AngHV) is one of the vital pathogenic agents found in the wild and cultured eel populations, which has brought significant losses to eel culture industry in China. In this study, AngHV ORF95 was characterized. Bioinformatics analysis showed that ORF95 putatively encodes a structural protein that is homologous to hemagglutinin-esterase (HE) protein of infectious salmon anemia virus (ISAV). Temporal transcription and expression analysis indicated that ORF95 is a viral late gene. Subcellular localization analysis revealed that ORF95 was predominantly localized in the cytoplasm. Further, western blot analysis indicated that ORF95 is a structural protein of virion envelope. These results provide a novel basis to make further efforts to clarify the function of ORF95 in the process of AngHV infection and the possibility to use ORF95 as antigen to develop AngHV subunit vaccine.
Identifiants
pubmed: 33929643
doi: 10.1007/s11262-021-01836-x
pii: 10.1007/s11262-021-01836-x
doi:
Substances chimiques
Hemagglutinins, Viral
0
Viral Fusion Proteins
0
hemagglutinin esterase
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
280-283Subventions
Organisme : Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences (CN)
ID : 2018R1019-4
Organisme : Public-Interest Scientific Institution Basal Research Fund of Fujian Province
ID : 2019R1027-4
Organisme : National Natural Science Foundation of China
ID : 31101933
Organisme : Natural Science Foundation of Fujian Province
ID : 2019J01109
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