Protective Effect of n-Butanol Extract from Viola yedoensis on Immunological Liver Injury.
Immunological liver injury
Viola yedoensis
coumarin
flavonoid
protective effect
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
19
12
2020
accepted:
29
04
2021
pubmed:
1
5
2021
medline:
24
8
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Viola yedoensis Makino was used to treat inflammation, viral hepatitis, acute pyogenic infection, and ulcerative carbuncles. However, the protective effect on immunological liver injury (ILI) of V. yedoensis had been rarely reported. This study aimed to explore the protective effect of n-butanol extract (BE) from V. yedoensis on ILI in vitro and in vivo. In vitro, the BE significantly inhibited the secretions of Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg) in the HepG2.2.15 cells and the replication of HBV DNA. The research data in vivo revealed that the BE reduced the levels of alanine transaminase (ALT), aspartate transaminase (AST), and methane dicarboxylic aldehyde (MDA) in liver tissues of the ConA-induced mice, while increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the effective contents of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and the BE could ameliorate liver histological lesions. These results motivated a further investigation into the chemical constituents of BE. Four coumarins (esculetin, prionanthoside, cichoriin, and esculin) and one flavonoid (quercetin-3-O-galactoside) were isolated from the BE by silica gel column chromatography and recrystallization, of which structures were eventually confirmed by
Identifiants
pubmed: 33929783
doi: 10.1002/cbdv.202001043
doi:
Substances chimiques
Hepatitis B Surface Antigens
0
Plant Extracts
0
Protective Agents
0
1-Butanol
8PJ61P6TS3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001043Subventions
Organisme : Natural Science Foundation of Ningxia Province
ID : 2002050801
Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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