Transmembrane Transport of Bicarbonate Unravelled*.

Bicarbonates Biological Transport Hydrogen-Ion Concentration Ion Transport Kinetics Lipid Bilayers
bicarbonate fluorescent probes ion transport membranes supramolecular chemistry

Journal

Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783

Informations de publication

Date de publication:
06 May 2021
Historique:
received: 08 02 2021
pubmed: 2 5 2021
medline: 11 5 2021
entrez: 1 5 2021
Statut: ppublish

Résumé

Anion receptors can be used to transport ions across lipid bilayers, which has potential for therapeutic applications. Synthetic bicarbonate transporters are of particular interest, as defects in transmembrane transport of bicarbonate are associated with various diseases. However, no convenient method exists to directly observe bicarbonate transport and study the mechanisms involved. Here, an assay is presented that allows the kinetics of bicarbonate transport into liposomes to be monitored directly and with great sensitivity. The assay utilises an encapsulated europium(III) complex, which exhibits a large increase in emission intensity upon binding bicarbonate. Mechanisms involving CO

Identifiants

DOI: 10.1002/chem.202100491 PMID: 33932059 PMC: PMC8251953
pubmed: 33932059
doi: 10.1002/chem.202100491
pmc: PMC8251953
doi:

Substances chimiques

Bicarbonates 0
Lipid Bilayers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7367-7375

Subventions

Organisme : EPSRC
ID : EP/S032339/1
Organisme : European Union's Horizon 2020
ID : 802727
Organisme : European Research Council (ERC)
Organisme : Fonds De La Recherche Scientifique - FNRS
Organisme : Wellcome Trust
ID : 204500/Z/16/Z
Pays : United Kingdom
Organisme : Grantová Agentura České Republiky
ID : No. 20-13922S
Organisme : Engineering and Physical Sciences Research Council
ID : EP/S032339/1
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : ULB
Organisme : Fonds de la Recherche Scientifique - FNRS
Organisme : European Research Council
ID : 802727
Pays : International
Organisme : Czech Science Foundation
ID : 20-13922S

Informations de copyright

© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.

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Auteurs

Luis Martínez-Crespo (L)

Université Libre de Bruxelles (ULB), Engineering of Molecular NanoSystems, Ecole polytechnique de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, 1050, Brussels, Belgium.
ORCID: 0000-0001-5395-5562

Sarah H Hewitt (SH)

Loughborough University, Department of Chemistry, Epinal Way, Loughborough, LE11 3TU, UK.
ORCID: 0000-0002-7137-1314

Nicola Alessandro De Simone (NA)

Masaryk University, Department of Chemistry and RECETOX, Faculty of Science, Kamenice 5, 625 00, Brno, Czech Republic.
ORCID: 0000-0002-9868-6957

Vladimír Šindelář (V)

Masaryk University, Department of Chemistry and RECETOX, Faculty of Science, Kamenice 5, 625 00, Brno, Czech Republic.
ORCID: 0000-0003-0090-5961

Anthony P Davis (AP)

University of Bristol, School of Chemistry, Cantock's Close, Bristol, BS8 1TS, UK.
ORCID: 0000-0001-5213-624X

Stephen Butler (S)

Loughborough University, Department of Chemistry, Epinal Way, Loughborough, LE11 3TU, UK.
ORCID: 0000-0001-8109-3330

Hennie Valkenier (H)

Université Libre de Bruxelles (ULB), Engineering of Molecular NanoSystems, Ecole polytechnique de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, 1050, Brussels, Belgium.
ORCID: 0000-0002-4409-0154

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Carbonates › Hydrogénocarbonates › Transmembrane Transport of Bicarbonate Unravelled*.
questionsmedicales.fr › Métabolisme › Transport biologique › Transmembrane Transport of Bicarbonate Unravelled*.
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Transmembrane Transport of Bicarbonate Unravelled*.
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des ions › Transmembrane Transport of Bicarbonate Unravelled*.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Transmembrane Transport of Bicarbonate Unravelled*.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Double couche lipidique › Transmembrane Transport of Bicarbonate Unravelled*.