Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study.
Biomarker
Heart failure
Prognosis
Testosterone
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
18
03
2021
received:
01
12
2020
accepted:
12
04
2021
pubmed:
3
5
2021
medline:
29
10
2021
entrez:
2
5
2021
Statut:
ppublish
Résumé
The increased incidence of heart failure in men suggests that endogenous sex hormones might play a role in the development of heart failure, but epidemiological data remain sparse. Here, we evaluated the predictive value of low testosterone levels on future heart failure in the large population-based FINRISK97 study. Baseline serum testosterone concentrations were measured in 7855 subjects (3865 men and 3990 women) of the FINRISK97 study. During a median follow-up (FU) of 13.8 years, a total of 564 heart failure events were recorded. The age-adjusted baseline testosterone levels did not differ significantly between subjects developing incident heart failure during FU and those without incident events during FU (men: 16.6 vs. 17.1 nmol/L, P = 0.75; women: 1.15 vs. 1.17 nmol/L, P = 0.32). Relevant statistically significant correlations of testosterone levels were found with high-density lipoprotein cholesterol levels (R = 0.22; P < 0.001), body mass index (R = -0.23; P < 0.001), and waist-to-hip ratio (R = -0.21; P < 0.001) in men, while statistically significant correlations in women were negligible in effect size. In sex-stratified Cox regression analyses, taking age into account, a quite strong association between low testosterone and incident heart failure was found in men [hazard ratio (HR) 1.51 (95% confidence interval, CI: 1.09-2.10); P = 0.020 for lowest vs. highest quarter], but not in women [HR 0.70 (95% CI: 0.49-0.98); P = 0.086 for lowest vs. highest quarter]. Nevertheless, this association turned non-significant after full adjustment including body mass index and waist-to-hip ratio, and testosterone levels were no longer predictive for incident heart failure-neither in men [HR 0.99 (95% CI: 0.70-1.42); P = 0.77 for lowest vs. highest quarter] nor in women [HR 0.92 (95% CI: 0.64-1.33); P = 0.99 for lowest vs. highest quarter]. Accordingly, Kaplan-Meier analyses did not reveal significant association of testosterone levels with heart failure. Low levels of testosterone do not independently predict future heart failure.
Identifiants
pubmed: 33934533
doi: 10.1002/ehf2.13384
pmc: PMC8318459
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2485-2491Informations de copyright
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Références
J Intern Med. 2019 Sep;286(3):317-325
pubmed: 31121065
J Am Heart Assoc. 2013 Jul 10;2(4):e000271
pubmed: 23842280
Clin Pharmacol Ther. 2011 Jul;90(1):52-66
pubmed: 21654741
Sports Med. 1996 Dec;22(6):367-90
pubmed: 8969015
Clin Chem. 2010 Apr;56(4):651-60
pubmed: 20185624
JACC Heart Fail. 2019 Mar;7(3):204-213
pubmed: 30819375
Eur J Prev Cardiol. 2018 Jul;25(11):1133-1139
pubmed: 29808758
Circ Res. 2017 Sep 29;121(8):905-907
pubmed: 28963185
Scand J Public Health. 2020 Feb;48(1):20-28
pubmed: 31068116
Biomolecules. 2018 Jun 28;8(3):
pubmed: 29958400
Biomolecules. 2018 Jul 20;8(3):
pubmed: 30037035
Clin Chem. 2010 May;56(5):861-4
pubmed: 20299677
J Clin Endocrinol Metab. 2020 Oct 1;105(10):
pubmed: 32770207
Int J Epidemiol. 2000 Feb;29(1):49-56
pubmed: 10750603
Biomolecules. 2018 Aug 09;8(3):
pubmed: 30096922
Circ Cardiovasc Genet. 2013 Feb;6(1):73-81
pubmed: 23247145
PLoS One. 2011;6(12):e25734
pubmed: 22162987
ESC Heart Fail. 2021 Aug;8(4):2485-2491
pubmed: 33934533
BMC Public Health. 2012 May 10;12:343
pubmed: 22574773
Eur J Epidemiol. 2014 Oct;29(10):777-90
pubmed: 25238720
Herz. 2009 Dec;34(8):607-13
pubmed: 20024640
Eur J Clin Invest. 2012 Mar;42(3):329-37
pubmed: 21950567
Int J Epidemiol. 2018 Jun 1;47(3):696-696i
pubmed: 29165699
BMC Med Genet. 2009 May 29;10:46
pubmed: 19480687
J Clin Endocrinol Metab. 1991 Nov;73(5):1016-25
pubmed: 1719016
J Androl. 1989 Sep-Oct;10(5):366-71
pubmed: 2592266
Clin Chem. 2014 Nov;60(11):1441-9
pubmed: 25139456
Br Med J. 1964 Jul 18;2(5402):177
pubmed: 14150898
PLoS One. 2012;7(12):e51441
pubmed: 23300549
J Clin Endocrinol Metab. 1979 Apr;48(4):633-8
pubmed: 429508
N Engl J Med. 2014 Nov 20;371(21):2032-4
pubmed: 25409377
Biomolecules. 2018 Aug 20;8(3):
pubmed: 30127326