Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications.
Journal
TheScientificWorldJournal
ISSN: 1537-744X
Titre abrégé: ScientificWorldJournal
Pays: United States
ID NLM: 101131163
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
10
2020
accepted:
19
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.
Sections du résumé
BACKGROUND
BACKGROUND
Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus.
RESULTS
RESULTS
In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications.
CONCLUSION
CONCLUSIONS
Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.
Identifiants
pubmed: 33935599
doi: 10.1155/2021/6641128
pmc: PMC8055414
doi:
Substances chimiques
Hypoglycemic Agents
0
Apigenin
7V515PI7F6
vitexin
9VP70K75OK
isovitexin
KTQ9R9MS0Q
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6641128Informations de copyright
Copyright © 2021 Ibrahim Luru Abdulai et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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