Whole-Brain Mapping the Direct Inputs of Dorsal and Ventral CA1 Projection Neurons.
direct inputs
dorsal CA1
projection neurons
rabies virus tracing
ventral CA1
Journal
Frontiers in neural circuits
ISSN: 1662-5110
Titre abrégé: Front Neural Circuits
Pays: Switzerland
ID NLM: 101477940
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
12
2020
accepted:
01
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
14
1
2022
Statut:
epublish
Résumé
The CA1, an important subregion of the hippocampus, is anatomically and functionally heterogeneous in the dorsal and ventral hippocampus. Here, to dissect the distinctions between the dorsal (dCA1) and ventral CA1 (vCA1) in anatomical connections, we systematically analyzed the direct inputs to dCA1 and vCA1 projection neurons (PNs) with the rabies virus-mediated retrograde trans-monosynaptic tracing system in Thy1-Cre mice. Our mapping results revealed that the input proportions and distributions of dCA1 and vCA1 PNs varied significantly. Inside the hippocampal region, dCA1 and vCA1 PNs shared the same upstream brain regions, but with distinctive distribution patterns along the rostrocaudal axis. The intrahippocampal inputs to the dCA1 and vCA1 exhibited opposite trends, decreasing and increasing gradually along the dorsoventral axis, respectively. For extrahippocampal inputs, dCA1 and vCA1 shared some monosynaptic projections from certain regions such as pallidum, striatum, hypothalamus, and thalamus. However, vCA1, not dCA1, received innervations from the subregions of olfactory areas and amygdala nuclei. Characterization of the direct input networks of dCA1 and vCA1 PNs may provide a structural basis to understand the differential functions of dCA1 and vCA1.
Identifiants
pubmed: 33935658
doi: 10.3389/fncir.2021.643230
pmc: PMC8079783
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
643230Informations de copyright
Copyright © 2021 Tao, Wang, Peng, Zhao, He, Yu, Liu, Jin and Xu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11794-9
pubmed: 19561297
Front Cell Neurosci. 2017 Apr 19;11:87
pubmed: 28469557
Nat Rev Neurosci. 2019 Apr;20(4):193-204
pubmed: 30778192
Nat Commun. 2017 Dec 19;8(1):2190
pubmed: 29259187
Behav Brain Res. 2018 Oct 1;351:138-151
pubmed: 29883593
J Physiol. 2012 Nov 15;590(22):5707-22
pubmed: 22988138
Behav Brain Res. 2005 Feb 10;157(1):127-37
pubmed: 15617779
Neurosci Biobehav Rev. 2016 Dec;71:409-417
pubmed: 27693699
Neurobiol Learn Mem. 2010 Jan;93(1):111-6
pubmed: 19733676
Neuropsychopharmacology. 2004 Jan;29(1):1-14
pubmed: 12942143
Nat Neurosci. 2018 Apr;21(4):484-493
pubmed: 29593317
Brain Res. 1988 Jun 14;452(1-2):255-72
pubmed: 3401733
Nat Neurosci. 2012 Nov;15(11):1563-71
pubmed: 23001061
Cell Tissue Res. 2018 Sep;373(3):565-575
pubmed: 29250747
Neuroscience. 2012 Mar 15;205:91-111
pubmed: 22245503
Nat Neurosci. 2017 Apr;20(4):559-570
pubmed: 28263300
Neuron. 2010 Jan 14;65(1):7-19
pubmed: 20152109
Hippocampus. 2018 Aug;28(8):602-616
pubmed: 29747244
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10825-30
pubmed: 12149439
Front Behav Neurosci. 2015 Jun 30;9:166
pubmed: 26175674
Hippocampus. 2016 Mar;26(3):341-61
pubmed: 26333017
Behav Neurosci. 2008 Jun;122(3):643-50
pubmed: 18513134
Neuropsychopharmacology. 2017 Jul;42(8):1715-1728
pubmed: 28294135
Brain Struct Funct. 2017 Jul;222(5):2421-2438
pubmed: 28008472
Eur J Neurosci. 2012 Mar;35(5):702-10
pubmed: 22339771
Behav Neurosci. 2004 Feb;118(1):97-110
pubmed: 14979786
Nat Rev Neurosci. 2014 Mar;15(3):181-92
pubmed: 24552786
Annu Rev Neurosci. 2007;30:181-207
pubmed: 17341158
Sci Rep. 2018 Jul 24;8(1):11136
pubmed: 30042474
Hippocampus. 2020 Mar;30(3):233-249
pubmed: 31490612
Epilepsy Res. 2018 Sep;145:63-72
pubmed: 29913405
Neuron. 2018 Feb 7;97(3):670-683.e6
pubmed: 29397273
Neuroscience. 1989;31(3):571-91
pubmed: 2687721
J Neurosci Res. 2017 Mar;95(3):797-820
pubmed: 26876924
Nat Rev Neurosci. 2009 Apr;10(4):272-82
pubmed: 19300446
Brain Res Rev. 2007 Nov;56(1):1-26
pubmed: 17559940
FEBS Lett. 2014 Aug 1;588(15):2470-6
pubmed: 24911200
Endocr Rev. 1991 May;12(2):118-34
pubmed: 2070776
Elife. 2016 Sep 19;5:
pubmed: 27642784
Science. 2008 Feb 29;319(5867):1260-4
pubmed: 18218862
Neuroscience. 2006;137(1):177-86
pubmed: 16309847
Hippocampus. 2001;11(5):551-68
pubmed: 11732708
Behav Brain Res. 2019 Nov 5;373:112078
pubmed: 31336139
J Neurosci. 2012 Mar 28;32(13):4386-99
pubmed: 22457489
Pain. 2018 Aug;159(8):1550-1561
pubmed: 29624516
Neuron. 2017 May 17;94(4):752-758.e1
pubmed: 28521130
Nat Rev Neurosci. 2017 Sep;18(9):547-558
pubmed: 28655882
Learn Mem. 2015 Aug 18;22(9):438-43
pubmed: 26286654
Front Neural Circuits. 2017 Jul 28;11:52
pubmed: 28804450
Neuron. 2016 May 4;90(3):622-34
pubmed: 27146266
Nature. 2015 Jan 15;517(7534):284-92
pubmed: 25592533
Neuroscience. 2013 Jan 3;228:139-62
pubmed: 23085097
Nat Rev Neurosci. 2016 Feb;17(2):89-102
pubmed: 26806628
Brain Struct Funct. 2012 Apr;217(2):191-209
pubmed: 21918815
Hippocampus. 2018 Jun;28(6):392-405
pubmed: 29473984
Nat Neurosci. 2014 Feb;17(2):269-79
pubmed: 24336151
Neuron. 2019 Nov 6;104(3):601-610.e4
pubmed: 31521441
Nat Commun. 2016 Jul 14;7:11935
pubmed: 27411738
Neuron. 2018 Aug 8;99(3):576-587.e5
pubmed: 30092214
J Neurophysiol. 2013 Apr;109(7):1940-53
pubmed: 23324324
Behav Neurosci. 2006 Aug;120(4):852-60
pubmed: 16893291
J Neurosci. 2017 Apr 5;37(14):3940-3955
pubmed: 28280255
Hippocampus. 2018 Feb;28(2):178-185
pubmed: 29232477
Nat Rev Neurosci. 2014 Oct;15(10):655-69
pubmed: 25234264
Ann N Y Acad Sci. 2000 Jun;911:1-24
pubmed: 10911864
Front Neurol Neurosci. 2014;34:6-17
pubmed: 24777126
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9697-701
pubmed: 7568200
Nat Commun. 2019 Mar 22;10(1):1341
pubmed: 30902981