Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines
Autophagy
/ drug effects
Cells, Cultured
Cytokines
/ metabolism
Dendritic Cells
/ drug effects
Gene Expression Profiling
Glycogen Synthase Kinase 3 beta
/ metabolism
Humans
Mycobacterium tuberculosis
/ immunology
Primary Cell Culture
Signal Transduction
/ drug effects
Sirolimus
/ pharmacology
TOR Serine-Threonine Kinases
/ metabolism
Tuberculosis
/ drug therapy
IFN
Mycobacterium tuberculosis
autophagy
host-directed therapy
rapalogs
transcriptome
translatome
tuberculosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
01
2021
accepted:
10
03
2021
entrez:
3
5
2021
pubmed:
4
5
2021
medline:
28
9
2021
Statut:
epublish
Résumé
In human primary dendritic cells (DC) rapamycin-an autophagy inducer and protein synthesis inhibitor-overcomes the autophagy block induced by
Identifiants
pubmed: 33936070
doi: 10.3389/fimmu.2021.649475
pmc: PMC8086600
doi:
Substances chimiques
Cytokines
0
MTOR protein, human
EC 2.7.1.1
GSK3B protein, human
EC 2.7.11.1
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
649475Informations de copyright
Copyright © 2021 Etna, Severa, Licursi, Pardini, Cruciani, Rizzo, Giacomini, Macchia, Palumbo, Stallone, Carella, Livingstone, Negri, Pellegrini and Coccia.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Immunol. 2020 Nov 12;11:603951
pubmed: 33262773
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7723-8
pubmed: 22550181
Annu Rev Immunol. 2015;33:563-606
pubmed: 25665078
J Exp Med. 2001 Nov 19;194(10):1421-32
pubmed: 11714749
Nat Immunol. 2005 Aug;6(8):777-84
pubmed: 16007092
J Med Food. 2012 Sep;15(9):788-94
pubmed: 22857612
FEMS Microbiol Rev. 2017 May 1;41(3):354-373
pubmed: 28369307
Proteomics. 2015 Sep;15(17):3020-9
pubmed: 26036210
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):E1204-13
pubmed: 22065737
J Immunol. 2011 Sep 1;187(5):2559-68
pubmed: 21813773
Sci Rep. 2015 Nov 25;5:17078
pubmed: 26602835
Blood. 2007 Feb 15;109(4):1584-92
pubmed: 17032918
Front Immunol. 2019 Jan 14;9:3145
pubmed: 30692999
J Proteome Res. 2020 Jun 5;19(6):2316-2336
pubmed: 32407090
Cell Mol Immunol. 2017 Dec;14(12):963-975
pubmed: 28890547
Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7
pubmed: 24243840
J Biol Chem. 2003 Jul 25;278(30):28130-8
pubmed: 12740386
Biochem J. 2012 Sep 15;446(3):509-16
pubmed: 22731491
J Biol Chem. 1998 Jun 26;273(26):16621-9
pubmed: 9632736
Vaccines (Basel). 2020 Feb 04;8(1):
pubmed: 32033104
J Immunol. 2011 May 1;186(9):5217-26
pubmed: 21422248
Biochem Biophys Res Commun. 2016 May 13;473(4):1229-1234
pubmed: 27079235
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Cell Mol Immunol. 2020 Sep;17(9):901-913
pubmed: 32728204
Nat Microbiol. 2016 Aug 15;1(9):16133
pubmed: 27562263
Nucleic Acids Res. 2003 Feb 15;31(4):e15
pubmed: 12582260
Mediators Inflamm. 2015;2015:854507
pubmed: 26640327
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
PLoS Pathog. 2018 Jan 4;14(1):e1006790
pubmed: 29300789
Lancet Infect Dis. 2018 Jul;18(7):e183-e198
pubmed: 29580819
iScience. 2019 Dec 20;22:299-313
pubmed: 31805434
Autophagy. 2012 Sep;8(9):1357-70
pubmed: 22885411
Mol Immunol. 2020 Feb;118:153-164
pubmed: 31884387
PLoS Pathog. 2012 Feb;8(2):e1002507
pubmed: 22319448
Immunity. 2008 Oct 17;29(4):565-77
pubmed: 18848473
Nat Immunol. 2014 Jun;15(6):503-11
pubmed: 24840981
J Clin Med. 2019 Feb 11;8(2):
pubmed: 30754665
Int Rev Immunol. 2019;38(4):172-179
pubmed: 31244354
Cell Immunol. 2004 Mar;228(1):34-41
pubmed: 15203318
Microb Pathog. 2019 May;130:156-168
pubmed: 30876870
J Biol Chem. 2014 Mar 7;289(10):6581-6591
pubmed: 24469448
J Exp Med. 2018 Nov 5;215(11):2919-2935
pubmed: 30337468
Am J Respir Cell Mol Biol. 2011 Jul;45(1):172-80
pubmed: 20889800
Cytokine. 2010 Oct-Nov;52(1-2):123-7
pubmed: 20409730
PLoS One. 2015 Jul 24;10(7):e0133482
pubmed: 26207988
Immunity. 2017 May 16;46(5):730-742
pubmed: 28514674
Infect Immun. 2009 Nov;77(11):4947-52
pubmed: 19720761
Sci Rep. 2018 Nov 9;8(1):16610
pubmed: 30413750
Blood. 2010 Jun 10;115(23):4758-69
pubmed: 20335217
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Semin Immunol. 2014 Dec;26(6):543-51
pubmed: 25453229
PLoS One. 2011;6(7):e22200
pubmed: 21779393
Pharm Res. 2016 Aug;33(8):1899-912
pubmed: 27095353
Cell Host Microbe. 2015 Jun 10;17(6):820-8
pubmed: 26048137
Cell Host Microbe. 2015 Jun 10;17(6):811-819
pubmed: 26048136