Decrease in CD38
ADP-ribosyl Cyclase 1
/ immunology
Adult
Animals
Double-Blind Method
Female
Humans
Hypersensitivity
/ immunology
Immunoglobulin G
/ blood
Male
Membrane Glycoproteins
/ immunology
Middle Aged
Pyroglyphidae
/ immunology
Sublingual Immunotherapy
/ methods
T-Lymphocyte Subsets
/ immunology
Th2 Cells
/ immunology
Treatment Outcome
CD38+TH2A
house dust mite
sublingual immunotherapy
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
20
04
2021
received:
01
02
2021
accepted:
22
04
2021
pubmed:
4
5
2021
medline:
1
3
2022
entrez:
3
5
2021
Statut:
ppublish
Résumé
In line with evidence for a role of pathogenic TH2A in seasonal allergies, we previously showed that individuals suffering from food allergy exhibited a decrease in circulating TH2A cells following multi-food immunotherapy. Herein, we aim to confirm the decline of TH2A cells in individuals undergoing house dust mite immunotherapy (HDM-AIT) and extend our observation to a new subset of CD38 expressing activated TH2A cells. The frequencies of TH2A and CD38 A decrease in TH2A cells was observed in both active and placebo groups. Interestingly, CD38 We confirm the value of monitoring TH2A cell frequencies in allergic individuals and extend this observation to perennial allergy to HDM. We highlight the interest of CD38 to better identify the subset of TH2A cell down-regulated by AIT. Finally, correlated cellular and humoral responses observed in immunoreactive individuals stress that coordinated pathways occur in the adaptive responses during AIT.
Sections du résumé
BACKGROUND
In line with evidence for a role of pathogenic TH2A in seasonal allergies, we previously showed that individuals suffering from food allergy exhibited a decrease in circulating TH2A cells following multi-food immunotherapy. Herein, we aim to confirm the decline of TH2A cells in individuals undergoing house dust mite immunotherapy (HDM-AIT) and extend our observation to a new subset of CD38 expressing activated TH2A cells.
METHODS
The frequencies of TH2A and CD38
RESULTS
A decrease in TH2A cells was observed in both active and placebo groups. Interestingly, CD38
CONCLUSIONS
We confirm the value of monitoring TH2A cell frequencies in allergic individuals and extend this observation to perennial allergy to HDM. We highlight the interest of CD38 to better identify the subset of TH2A cell down-regulated by AIT. Finally, correlated cellular and humoral responses observed in immunoreactive individuals stress that coordinated pathways occur in the adaptive responses during AIT.
Substances chimiques
Immunoglobulin G
0
Membrane Glycoproteins
0
CD38 protein, human
EC 3.2.2.5
ADP-ribosyl Cyclase 1
EC 3.2.2.6
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1057-1068Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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