Deletion of
cadherin
kidney development
urinary concentrating ability
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
4
5
2021
medline:
31
7
2021
entrez:
3
5
2021
Statut:
ppublish
Résumé
Ksp-cadherin (cadherin-16) is an atypical member of the cadherin superfamily of cell adhesion molecules that is ubiquitously expressed on the basolateral membrane of epithelial cells lining the nephron and the collecting system of the mammalian kidney. The principal aim of the present study was to determine if Ksp-cadherin played a critical role in the development and maintenance of the adult mammalian kidney by generating and evaluating a mouse line deficient in Ksp-cadherin. Ksp-null mutant animals were viable and fertile, and kidneys from both neonates and adults showed no evidence of structural abnormalities. Immunolocalization and Western blot analyses of Na
Identifiants
pubmed: 33938239
doi: 10.1152/ajprenal.00556.2020
pmc: PMC8285649
doi:
Substances chimiques
Aqp2 protein, mouse
0
Aquaporin 2
0
Cadherins
0
Cdh1 protein, mouse
0
Cdh16 protein, mouse
0
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F1106-F1122Subventions
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : P01DK017433
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : P30DK114857
Organisme : NIDDK NIH HHS
ID : P30 DK079310
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK114857
Pays : United States
Organisme : NIDDK NIH HHS
ID : P01 DK017433
Pays : United States
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