Small nucleolar RNA host genes promoting epithelial-mesenchymal transition lead cancer progression and metastasis.
EMT
cancer
long non-coding RNAs
small nucleolar RNA host genes
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
22
04
2021
received:
03
03
2021
accepted:
29
04
2021
pubmed:
4
5
2021
medline:
27
1
2022
entrez:
3
5
2021
Statut:
ppublish
Résumé
The small nucleolar RNA host genes (SNHGs) belong to the long non-coding RNAs and are reported to be able to influence all three levels of cellular information-bearing molecules, that is, DNA, RNA, and proteins, resulting in the generation of complex phenomena. As the host genes of the small nucleolar RNAs (snoRNAs), they are commonly localized in the nucleolus, where they exert multiple regulatory functions orchestrating cellular homeostasis and differentiation as well as metastasis and chemoresistance. Indeed, worldwide literature has reported their involvement in the epithelial-mesenchymal transition (EMT) of different histotypes of cancer, being able to exploit peculiar features, for example, the possibility to act both in the nucleus and the cytoplasm. Moreover, SNHGs regulation is a fundamental topic to better understand their role in tumor progression albeit such mechanism is still debated. Here, we reviewed the biological functions of SNHGs in particular in the EMT process and discussed the perspectives for new cancer therapies.
Substances chimiques
RNA, Neoplasm
0
RNA, Small Nucleolar
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
825-842Informations de copyright
© 2021 International Union of Biochemistry and Molecular Biology.
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