Persistent fontanelles in Chihuahuas. Part II: Association with craniocervical junction abnormalities, syringomyelia, and ventricular volume.
Chiari-like malformation
craniocervical junction
syringomyelia
ventriculomegaly
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
31
03
2021
received:
03
12
2020
accepted:
01
04
2021
pubmed:
4
5
2021
medline:
24
7
2021
entrez:
3
5
2021
Statut:
ppublish
Résumé
Persistent fontanelles (PFs) are, in Chihuahuas, almost ubiquitous. Furthermore, Chihuahuas are predisposed to other craniomorphological abnormalities, including syringomyelia (SM), ventriculomegaly, and craniocervical junction (CCJ) overcrowding resulting in neural tissue deviation. It is, however, undetermined if PFs are more common in dogs with these structural abnormalities, and their etiology is unknown. Persistent fontanelles are more numerous and larger in Chihuahuas with low body weight, older age, SM, dilated fourth ventricle, ventriculomegaly, and CCJ overcrowding. Fifty client-owned Chihuahuas. Cross-sectional study evaluating the association of both the number of cranial sutures affected by PFs (NAS) and total fontanelle area (TFA), based on computed tomography with SM, fourth ventricle dilatation, lateral ventricle volume, and extent of neural tissue compression at the CCJ based on magnetic resonance images. The NASs was higher and TFA larger in dogs with low body weight (NAS: P = .007; 95% confidence interval [CI] = 0.384-0.861; TFA: P = .002; 95% CI = -1.91 to -0.478), larger lateral ventricles (NAS: P ≤ .001; 95% CI = 1.04-1.15; TFA: P ≤ .001; 95% CI = 0.099-0.363), and more severe neural tissue compression at the CCJ (NAS: P ≤ .001; 95% CI = 1.26-2.06; TFA: P = .03; 95% CI = 0.066-1.13). Similarly, dogs with SM (NAS: P = .004; 95% CI = 1.26-3.32; TFA: mean ± SD, 130 ± 217 mm Persistent fontanelles are associated with small size, SM, ventriculomegaly, and CCJ overcrowding.
Sections du résumé
BACKGROUND
BACKGROUND
Persistent fontanelles (PFs) are, in Chihuahuas, almost ubiquitous. Furthermore, Chihuahuas are predisposed to other craniomorphological abnormalities, including syringomyelia (SM), ventriculomegaly, and craniocervical junction (CCJ) overcrowding resulting in neural tissue deviation. It is, however, undetermined if PFs are more common in dogs with these structural abnormalities, and their etiology is unknown.
HYPOTHESIS/OBJECTIVES
OBJECTIVE
Persistent fontanelles are more numerous and larger in Chihuahuas with low body weight, older age, SM, dilated fourth ventricle, ventriculomegaly, and CCJ overcrowding.
ANIMALS
METHODS
Fifty client-owned Chihuahuas.
METHODS
METHODS
Cross-sectional study evaluating the association of both the number of cranial sutures affected by PFs (NAS) and total fontanelle area (TFA), based on computed tomography with SM, fourth ventricle dilatation, lateral ventricle volume, and extent of neural tissue compression at the CCJ based on magnetic resonance images.
RESULTS
RESULTS
The NASs was higher and TFA larger in dogs with low body weight (NAS: P = .007; 95% confidence interval [CI] = 0.384-0.861; TFA: P = .002; 95% CI = -1.91 to -0.478), larger lateral ventricles (NAS: P ≤ .001; 95% CI = 1.04-1.15; TFA: P ≤ .001; 95% CI = 0.099-0.363), and more severe neural tissue compression at the CCJ (NAS: P ≤ .001; 95% CI = 1.26-2.06; TFA: P = .03; 95% CI = 0.066-1.13). Similarly, dogs with SM (NAS: P = .004; 95% CI = 1.26-3.32; TFA: mean ± SD, 130 ± 217 mm
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Persistent fontanelles are associated with small size, SM, ventriculomegaly, and CCJ overcrowding.
Identifiants
pubmed: 33939205
doi: 10.1111/jvim.16123
pmc: PMC8295681
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1848-1856Subventions
Organisme : Agria/Svenska Kennelklubben Forskningsfond
ID : N2018-0024
Organisme : The Finnish Veterinary Foundation
Informations de copyright
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
J Vet Intern Med. 2015 May-Jun;29(3):887-92
pubmed: 25996662
J Neurosurg Pediatr. 2016 Apr;17(4):469-75
pubmed: 26613275
Acta Vet Hung. 2017 Mar;65(1):1-12
pubmed: 28244335
Life (Basel). 2021 Feb 12;11(2):
pubmed: 33673129
Vet Radiol Ultrasound. 2013 Sep-Oct;54(5):497-503
pubmed: 23782353
Am J Vet Res. 2007 Jun;68(6):610-3
pubmed: 17542693
PLoS One. 2014 Feb 12;9(2):e88120
pubmed: 24533070
PLoS One. 2017 Jan 25;12(1):e0169898
pubmed: 28121988
Vet J. 2013 Sep;197(3):896-7
pubmed: 23755937
Vet J. 2011 Dec;190(3):359-63
pubmed: 21216639
Canine Genet Epidemiol. 2014 Jul 29;1:9
pubmed: 26401326
Front Vet Sci. 2018 Nov 28;5:280
pubmed: 30547039
Pediatr Neurol. 2015 Nov;53(5):394-401
pubmed: 26371995
BMC Vet Res. 2012 Nov 08;8:215
pubmed: 23136935
Nat Commun. 2016 Jan 22;7:10460
pubmed: 26795439
Neurosurgery. 1996 Oct;39(4):691-9
pubmed: 8880760
J Vet Intern Med. 2015 May-Jun;29(3):882-6
pubmed: 25929341
Front Vet Sci. 2017 Aug 22;4:137
pubmed: 28879204
PLoS One. 2017 Jan 25;12(1):e0170315
pubmed: 28122014
Vet Radiol Ultrasound. 2009 Jan-Feb;50(1):37-46
pubmed: 19241752
AJNR Am J Neuroradiol. 2003 Jan;24(1):45-51
pubmed: 12533326
BMC Vet Res. 2012 Sep 06;8:158
pubmed: 22954070
PLoS One. 2015 May 04;10(5):e0124174
pubmed: 25938575
Science. 2007 Apr 6;316(5821):112-5
pubmed: 17412960
J Vet Intern Med. 2021 Jul;35(4):1834-1847
pubmed: 34028887
Front Endocrinol (Lausanne). 2013 Feb 04;4:6
pubmed: 23382729
Vet Radiol Ultrasound. 2009 Sep-Oct;50(5):467-76
pubmed: 19788029
Mamm Genome. 2012 Dec;23(11-12):780-90
pubmed: 22903739
Dev Dyn. 2000 Dec;219(4):472-85
pubmed: 11084647
J Vet Intern Med. 2017 Nov;31(6):1771-1781
pubmed: 28892202
J Small Anim Pract. 2010 Jul;51(7):382-6
pubmed: 20536691
J Vet Intern Med. 2021 Jul;35(4):1848-1856
pubmed: 33939205