Effects of Low-dose Mercury Exposure in Newborns on mRNA Expression Profiles.
Differentially expressed genes
Low‐dose Hg exposure
Newborns
Umbilical cord blood
mRNA
Journal
Bulletin of environmental contamination and toxicology
ISSN: 1432-0800
Titre abrégé: Bull Environ Contam Toxicol
Pays: United States
ID NLM: 0046021
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
22
02
2021
accepted:
21
04
2021
pubmed:
5
5
2021
medline:
3
11
2021
entrez:
4
5
2021
Statut:
ppublish
Résumé
This study was designed to investigate the molecular mechanism of mercury (Hg) toxicity in the newborns by mRNA sequencing (mRNA-seq). A questionnaire survey, routine blood parameters of pregnant women, and umbilical cord blood (UCB) of newborns were collected. The median (25th percentile, 75th percentile) of total Hg (THg) concentrations in UCB of newborns was 3.63 (2.50, 6.19) µg/L. A total of 504 differentially expressed genes of mRNA were revealed between the case and control group, including 456 upregulated and 48 downregulated genes. The Gene Ontology (GO) analysis showed that differentially expressed genes were primarily involved in mitophagy, hemoglobin complex, and oxygen carrier activity. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that the most differentially expressed genes were annotated in Huntington's disease, Parkinson's disease, and Alzheimer's disease. The qRT-PCR was used to validate the results of mRNA-seq. Low-dose Hg exposure could increase blood NE# and WBC in the pregnant women. This study provides scientific evidences on mechanism of Hg toxicity in newborns.
Identifiants
pubmed: 33944966
doi: 10.1007/s00128-021-03249-w
pii: 10.1007/s00128-021-03249-w
doi:
Substances chimiques
RNA, Messenger
0
Mercury
FXS1BY2PGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
975-981Subventions
Organisme : National Natural Science Foundation of China
ID : U1812403
Organisme : Key Laboratory of Environmental Pollution Monitoring and Disease Control
ID : GMU-2020-HJZ-04
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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