Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries.
Adenocarcinoma, Clear Cell
/ drug therapy
Animals
Antineoplastic Agents
/ pharmacology
Cell Line, Tumor
DNA-Binding Proteins
/ antagonists & inhibitors
Electron Transport Complex I
/ antagonists & inhibitors
Female
Gene Expression Regulation, Neoplastic
/ drug effects
Gene Knockdown Techniques
Humans
Membrane Potential, Mitochondrial
/ drug effects
Mice
Mice, Nude
Mitochondria
/ drug effects
Neoplasm Proteins
/ antagonists & inhibitors
Ovarian Neoplasms
/ drug therapy
Oxadiazoles
/ pharmacology
Oxidative Phosphorylation
/ drug effects
Oxygen Consumption
/ drug effects
Piperidines
/ pharmacology
RNA Interference
RNA, Small Interfering
/ genetics
Random Allocation
Spheroids, Cellular
Transcription Factors
/ antagonists & inhibitors
Xenograft Model Antitumor Assays
ARID1A
OCCC
mitochondria
ovarian cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Apr 2021
29 Apr 2021
Historique:
received:
08
04
2021
revised:
23
04
2021
accepted:
27
04
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Ovarian clear cell carcinoma (OCCC) is a rare but chemorefractory tumor. About 50% of all OCCC patients have inactivating mutations of
Identifiants
pubmed: 33947138
pii: ijms22094750
doi: 10.3390/ijms22094750
pmc: PMC8124918
pii:
doi:
Substances chimiques
ARID1A protein, human
0
Antineoplastic Agents
0
DNA-Binding Proteins
0
IACS-010759
0
Neoplasm Proteins
0
Oxadiazoles
0
Piperidines
0
RNA, Small Interfering
0
Transcription Factors
0
Electron Transport Complex I
EC 7.1.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01-GM130800
Pays : United States
Organisme : Ovarian Cancer Academy
ID : OC160377
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