Activated CD4
Antibodies, Viral
/ immunology
Antibody Formation
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Humans
Immunity, Mucosal
/ immunology
Influenza A virus
/ immunology
Influenza Vaccines
/ immunology
Influenza, Human
/ immunology
Lipopolysaccharide Receptors
/ immunology
Monocytes
/ immunology
Orthomyxoviridae Infections
/ immunology
antibody
cellular immunity
humoral immunity
immune correlate
infection
influenza
monocytes
mucosal immunity
respiratory virus
seroconversion
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
received:
28
09
2020
revised:
25
01
2021
accepted:
10
03
2021
entrez:
5
5
2021
pubmed:
6
5
2021
medline:
6
5
2021
Statut:
epublish
Résumé
The failure to mount an antibody response following viral infection or seroconversion failure is a largely underappreciated and poorly understood phenomenon. Here, we identified immunologic markers associated with robust antibody responses after influenza virus infection in two independent human cohorts, SHIVERS and FLU09, based in Auckland, New Zealand and Memphis, Tennessee, USA, respectively. In the SHIVERS cohort, seroconversion significantly associates with (1) hospitalization, (2) greater numbers of proliferating, activated CD4
Identifiants
pubmed: 33948570
doi: 10.1016/j.xcrm.2021.100237
pii: S2666-3791(21)00053-7
pmc: PMC8080109
doi:
Substances chimiques
Antibodies, Viral
0
CD14 protein, human
0
Influenza Vaccines
0
Lipopolysaccharide Receptors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Pagination
100237Subventions
Organisme : NIAID NIH HHS
ID : HHSN266200700005C
Pays : United States
Investigateurs
Nikki Turner
(N)
Michael Baker
(M)
Cameron Grant
(C)
Colin McArthur
(C)
Sally Roberts
(S)
Adrian Trenholmes
(A)
Conroy Wong
(C)
Susan Taylor
(S)
Mark Thompson
(M)
Diane Gross
(D)
Jazmin Duque
(J)
Kathryn Haven
(K)
Debbie Aley
(D)
Pamela Muponisi
(P)
Bhamita Chand
(B)
Yan Chen
(Y)
Laurel Plewes
(L)
Frann Sawtell
(F)
Shirley Lawrence
(S)
Reniza Cogcoy
(R)
Jo Smith
(J)
Franie Gravidez
(F)
Mandy Ma
(M)
Shona Chamberlin
(S)
Kirstin Davey
(K)
Tania Knowles
(T)
Jo-Ann McLeish
(JA)
Angela Todd
(A)
Judy Bocacao
(J)
Wendy Gunn
(W)
Pamela Kawakami
(P)
Susan Walker
(S)
Robyn Madge
(R)
Nicole Moore
(N)
Fahimeh Rahnama
(F)
Helen Qiao
(H)
Fifi Tse
(F)
Mahtab Zibaei
(M)
Tirzah Korrapadu
(T)
Louise Optland
(L)
Cecilia Dela Cruz
(C)
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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