Structural alterations in brainstem, basal ganglia and thalamus associated with parkinsonism in schizophrenia spectrum disorders.
Basal ganglia
Brainstem
Freesurfer
MRI
Parkinsonism
Sensorimotor domain
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
04
02
2021
accepted:
22
04
2021
pubmed:
6
5
2021
medline:
19
2
2022
entrez:
5
5
2021
Statut:
ppublish
Résumé
The relative roles of brainstem, thalamus and striatum in parkinsonism in schizophrenia spectrum disorder (SSD) patients are largely unknown. To determine whether topographical alterations of the brainstem, thalamus and striatum contribute to parkinsonism in SSD patients, we conducted structural magnetic resonance imaging (MRI) of SSD patients with (SSD-P, n = 35) and without (SSD-nonP, n = 64) parkinsonism, as defined by a Simpson and Angus Scale (SAS) total score of ≥ 4 and < 4, respectively, in comparison with healthy controls (n = 20). FreeSurfer v6.0 was used for segmentation of four brainstem regions (medulla oblongata, pons, superior cerebellar peduncle and midbrain), caudate nucleus, putamen and thalamus. Patients with parkinsonism had significantly smaller medulla oblongata (p = 0.01, false discovery rate (FDR)-corrected) and putamen (p = 0.02, FDR-corrected) volumes when compared to patients without parkinsonism. Across the entire patient sample (n = 99), significant negative correlations were identified between (a) medulla oblongata volumes and both SAS total (p = 0.034) and glabella-salivation (p = 0.007) scores, and (b) thalamic volumes and both SAS total (p = 0.033) and glabella-salivation (p = 0.007) scores. These results indicate that brainstem and thalamic structures as well as basal ganglia-based motor circuits play a crucial role in the pathogenesis of parkinsonism in SSD.
Identifiants
pubmed: 33950322
doi: 10.1007/s00406-021-01270-y
pii: 10.1007/s00406-021-01270-y
pmc: PMC8563526
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455-1464Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : HI 1928/2-1
Organisme : Deutsche Forschungsgemeinschaft
ID : WO 1883/6-1
Organisme : Bundesministerium für Bildung und Forschung
ID : 01GQ1102
Informations de copyright
© 2021. The Author(s).
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