Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films.

Chemistry, Pharmaceutical Drug Liberation Hydrogen-Ion Concentration Hypromellose Derivatives Saquinavir Solubility
Drug release testing method Franz diffusion cell Microenvironmental pH Saquinavir buccal film UV/Vis imaging

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Aug 2021
Historique:
received: 01 03 2021
revised: 22 04 2021
accepted: 26 04 2021
pubmed: 6 5 2021
medline: 22 6 2021
entrez: 5 5 2021
Statut: ppublish

Résumé

Buccal films containing a pH modifying excipient may be able to increase bioavailability of drugs with pH-dependent solubility such as saquinavir. Access to suitable in vitro drug release testing methods may facilitate buccal formulation development. This study aimed to explore two release testing methods for characterising buccal films and to elucidate the relationship between microenvironmental pH (pH

Identifiants

DOI: 10.1016/j.ejps.2021.105867 PMID: 33951482
pubmed: 33951482
pii: S0928-0987(21)00168-8
doi: 10.1016/j.ejps.2021.105867
pii:
doi:

Substances chimiques

Hypromellose Derivatives 3NXW29V3WO
Saquinavir L3JE09KZ2F

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105867

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Shaolong He (S)

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Jette Jacobsen (J)

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Carsten Uhd Nielsen (CU)

Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

Natalja Genina (N)

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Jesper Østergaard (J)

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address: jesper.ostergaard@sund.ku.dk.

Huiling Mu (H)

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › Exploration of in vitro drug release testing...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Exploration of in vitro drug release testing...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Exploration of in vitro drug release testing...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Dérivés de l'hypromellose › Exploration of in vitro drug release testing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Saquinavir › Exploration of in vitro drug release testing...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Exploration of in vitro drug release testing...