Evidence of altered metabolism of cellular membranes in bipolar disorder comorbid with post-traumatic stress disorder.
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
05
10
2020
revised:
06
04
2021
accepted:
08
04
2021
pubmed:
6
5
2021
medline:
6
7
2021
entrez:
5
5
2021
Statut:
ppublish
Résumé
In proton magnetic resonance spectroscopy (¹H MRS) studies, aberrant levels of choline-containing compounds that include glycerophosphocholine plus phosphocholine (GPC+PC), can signify alterations in the metabolism of cellular membrane phospholipids (MPLs) from a healthy baseline. In a recent ¹H MRS study, we reported increased GPC+PC in cortical and subcortical areas of adult patients with bipolar disorder I (BP-I). Post-traumatic stress disorder (PTSD) can worsen the severity of BP-I, but it is unclear whether the effect of a PTSD comorbidity in BP-I is associated with altered MPL metabolism. The purpose of this study was to re-investigate the ¹H MRS data to determine whether the regional extent of elevated GPC+PC was greater in BP-I patients with PTSD (BP-I
Identifiants
pubmed: 33951550
pii: S0165-0327(21)00335-9
doi: 10.1016/j.jad.2021.04.011
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-87Informations de copyright
Copyright © 2021. Published by Elsevier B.V.