A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma.

Adenocarcinoma Animals CD8-Positive T-Lymphocytes Immunologic Memory Leukocytes, Mononuclear Mice T-Lymphocyte Subsets

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
05 05 2021
Historique:
received: 17 04 2020
revised: 30 12 2020
accepted: 01 04 2021
entrez: 6 5 2021
pubmed: 7 5 2021
medline: 13 7 2021
Statut: ppublish

Résumé

In humans, the natural killer (NK) cell marker CD161 identifies several subsets of T cells, including a polyclonal CD8 αβ T cell receptor-expressing subset with characteristic specificity for tissue-localized viruses. This subset also displays enhanced cytotoxic and memory phenotypes. Here, we characterized this unique T cell subset and determined its potential suitability for use in chimeric antigen receptor (CAR) T cell therapy. In mice, gene expression profiling among the CD161-equivalent CD8

Identifiants

DOI: 10.1126/scitranslmed.abc3196 PMID: 33952672 PMC: PMC10316998
pubmed: 33952672
pii: 13/592/eabc3196
doi: 10.1126/scitranslmed.abc3196
pmc: PMC10316998
mid: NIHMS1912538
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127387
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036211
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR024574
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Vanaja Konduri (V)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0001-5057-4502

Sujith K Joseph (SK)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0003-4596-1270

Tiara T Byrd (TT)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-0272-8041

Zeid Nawas (Z)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0001-6603-7664

Jonathan Vazquez-Perez (J)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-6750-3468

Colby J Hofferek (CJ)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-1051-0827

Matthew M Halpert (MM)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-3173-4061

Dongliang Liu (D)

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

Zhengdong Liang (Z)

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0003-4861-3941

Yunyu Baig (Y)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-3333-3368

Vita S Salsman (VS)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.

Damilola Oyewole-Said (D)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0001-8208-7629

Anna Tsimelzon (A)

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.

Briana A Burns (BA)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-6709-9581

Changyi Chen (C)

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Jonathan M Levitt (JM)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.

Qizhi Yao (Q)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Michael E. DeBakey VA Medical Center, Center for Translational Research on Inflammatory Diseases (CTRID), Houston, TX 77030, USA.
ORCID: 0000-0002-2267-0588

Nabil M Ahmed (NM)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0002-0982-8424

Meenakshi Hegde (M)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

William K Decker (WK)

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. decker@bcm.edu.
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0003-0992-5838

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › A subset of cytotoxic effector memory T cells...
questionsmedicales.fr › Eucaryotes › Animaux › A subset of cytotoxic effector memory T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › A subset of cytotoxic effector memory T cells...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › A subset of cytotoxic effector memory T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › A subset of cytotoxic effector memory T cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A subset of cytotoxic effector memory T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › A subset of cytotoxic effector memory T cells...