The human memory T cell compartment changes across tissues of the female reproductive tract.
Antigens, Surface
/ metabolism
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Female
Gene Expression Profiling
Genitalia, Female
/ physiology
Humans
Immunologic Memory
Immunophenotyping
Memory T Cells
/ immunology
Mucous Membrane
/ immunology
Organ Specificity
T-Lymphocyte Subsets
/ immunology
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
25
11
2020
accepted:
14
04
2021
revised:
12
04
2021
pubmed:
7
5
2021
medline:
28
12
2021
entrez:
6
5
2021
Statut:
ppublish
Résumé
Memory CD4 T cells in tissues fulfill numerous functions that are critical for local immune homeostasis and protection against pathogens. Previous studies have highlighted the phenotypic and functional heterogeneity of circulating and tissue-resident memory CD4 T cells across different human tissues such as skin, lung, liver, and colon. Comparatively little is known in regard to memory CD4 T cells across tissues of the female reproductive tract (FRT). We examined CD4 T cells in donor-matched vaginal, ecto- and endocervical tissues, which differ in mucosal structure and exposure to external environmental stimuli. We hypothesized that this could be reflected by tissue-specific differences in the memory CD4 T cell compartment. We found differences in CD4 subset distribution across these tissues. Specifically, CD69
Identifiants
pubmed: 33953338
doi: 10.1038/s41385-021-00406-6
pii: S1933-0219(22)00185-4
pmc: PMC8225572
mid: NIHMS1694115
doi:
Substances chimiques
Antigens, Surface
0
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
862-872Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007509
Pays : United States
Organisme : NIDCR NIH HHS
ID : DP2 DE023321
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121129
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123323
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141435
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007140
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116292
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040386
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131914
Pays : United States
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