Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs.
Adoptive Transfer
Animals
Animals, Genetically Modified
Anti-Asthmatic Agents
/ pharmacology
Antigens, Plant
Asthma
/ drug therapy
Bronchoconstriction
/ drug effects
Cells, Cultured
Cytokines
/ metabolism
Disease Models, Animal
Epitopes, T-Lymphocyte
/ drug effects
Humans
Immunoglobulin Fab Fragments
/ pharmacology
Immunoglobulin Fc Fragments
/ pharmacology
Inflammation Mediators
/ metabolism
Lung
/ drug effects
Lymphocyte Activation
/ drug effects
Mice, Inbred C57BL
Ovalbumin
Plant Extracts
T-Lymphocytes, Regulatory
/ drug effects
T regulatory cells (Tregs)
Tregitope
adoptive transfer
allergic airways disease (AAD)
allergic asthma
induced Tregs (iTregs)
murine model of asthma
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
11
2020
accepted:
26
02
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
23
9
2021
Statut:
epublish
Résumé
Tregitopes (T regulatory epitopes) are IgG-derived peptides with high affinity to major histocompatibility complex class II (MHCII), that are known to promote tolerance by activating T regulatory cell (Treg) activity. Here we characterized the effect of IgG Tregitopes in a well-established murine model of allergic asthma, demonstrating
Identifiants
pubmed: 33953711
doi: 10.3389/fimmu.2021.634509
pmc: PMC8089381
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Antigens, Plant
0
Cytokines
0
Epitopes, T-Lymphocyte
0
Immunoglobulin Fab Fragments
0
Immunoglobulin Fc Fragments
0
Inflammation Mediators
0
Plant Extracts
0
ragweed pollen
0
Ovalbumin
9006-59-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
634509Subventions
Organisme : CIHR
ID : 246796
Pays : Canada
Informations de copyright
Copyright © 2021 Dembele, Tao, Massoud, Miah, Lelias, De Groot and Mazer.
Déclaration de conflit d'intérêts
AG is a senior officer and shareholder, and SM and SL are employees of EpiVax, Inc., a company specializing in immunoinformatic analysis. EpiVax, Inc. own patents to technologies utilized by associated authors in the research reported here. BM holds research funds from Canadian Institutes for Health Research, National Sciences Engineering and Research Council, The McGill University Health Center Foundation and The Montreal Children’s Hospital Foundation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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