Natural soluble epoxide hydrolase inhibitors from Alisma orientale and their potential mechanism with soluble epoxide hydrolase.

Alisma / chemistry Enzyme Inhibitors / chemistry Epoxide Hydrolases / antagonists & inhibitors Inhibitory Concentration 50 Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Molecular Structure Pharmacokinetics Plant Extracts / chemistry Protein Conformation Triterpenes / chemistry
Inhibition kinetics Molecular dynamics simulations Soluble epoxide hydrolase

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Jul 2021
Historique:
received: 18 03 2021
revised: 26 04 2021
accepted: 29 04 2021
pubmed: 7 5 2021
medline: 27 7 2021
entrez: 6 5 2021
Statut: ppublish

Résumé

Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and 3β-hydroxy-alisol G (2) were isolated from Alisma orientale and identified as new sEH inhibitors with IC

Identifiants

DOI: 10.1016/j.ijbiomac.2021.04.187 PMID: 33957203
pubmed: 33957203
pii: S0141-8130(21)00960-0
doi: 10.1016/j.ijbiomac.2021.04.187
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Plant Extracts 0
Triterpenes 0
Epoxide Hydrolases EC 3.3.2.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

811-817

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Wen-Yu Zhao (WY)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Xin-Yue Zhang (XY)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Mei-Rong Zhou (MR)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Xiang-Ge Tian (XG)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Xia Lv (X)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Hou-Li Zhang (HL)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Sa Deng (S)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Bao-Jing Zhang (BJ)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.

Cheng-Peng Sun (CP)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China. Electronic address: suncp146@163.com.

Xiao-Chi Ma (XC)

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China. Electronic address: maxc1978@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Alismatidae › Alismataceae › Alisma › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Epoxide hydrolase › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Natural soluble epoxide hydrolase inhibitors...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Natural soluble epoxide hydrolase inhibitors...