Promotion of the anticancer activity of curcumin based on a metal-polyphenol networks delivery system.
Anti-metastasis
Anticancer
Apoptosis
Curcumin
Epigallocatechin gallate
Metal-polyphenol networks
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
01 Jun 2021
01 Jun 2021
Historique:
received:
28
12
2020
revised:
14
04
2021
accepted:
22
04
2021
pubmed:
7
5
2021
medline:
22
6
2021
entrez:
6
5
2021
Statut:
ppublish
Résumé
Curcumin (Cur), a hydrophobic active pharmaceutical ingredient with high anticancer activity, has poor water solubility and low bioavailability. Although many delivery systems have been developed to improve their bioavailability, some limitation such as low drug loading efficiency and poor stability are still remained. The metal-polyphenol networks (MPNs) delivery system designed in this subject solved above problems and effectively improved the anticancer activity of Cur. The synthesized Cur@EGCG-Fe(III) is consisting of epigallocatechin gallate (EGCG), iron chloride (FeCl
Identifiants
pubmed: 33957265
pii: S0378-5173(21)00455-5
doi: 10.1016/j.ijpharm.2021.120650
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ferric Compounds
0
Polyphenols
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120650Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.