Nicotinamide and its effects on endothelial dysfunction and secretion of antiangiogenic factors by primary human placental cells and tissues.

Angiogenesis Inhibitors / metabolism Blood Vessels / drug effects Cells, Cultured Endothelium, Vascular / drug effects Female Human Umbilical Vein Endothelial Cells / drug effects Humans Niacinamide / pharmacology Placenta / blood supply Pregnancy Primary Cell Culture
Nicotinamide Placenta Preeclampsia Soluble endoglin sFlt-1

Journal

Placenta
ISSN: 1532-3102
Titre abrégé: Placenta
Pays: Netherlands
ID NLM: 8006349

Informations de publication

Date de publication:
06 2021
Historique:
received: 27 10 2020
revised: 29 03 2021
accepted: 13 04 2021
pubmed: 7 5 2021
medline: 27 1 2022
entrez: 6 5 2021
Statut: ppublish

Résumé

Preeclampsia is a serious pregnancy complication associated with elevated antiangiogenic markers and endothelial dysfunction. Recently nicotinamide (vitamin B3) was shown to reduce high blood pressure and proteinuria in mice models of the disease. Using primary human pregnancy tissue we show nicotinamide did not change antiangiogenic factor secretion including soluble fms-like tyrosine kinase 1 or soluble endoglin from primary cytotrophoblasts and placental explants. Furthermore, it did not reverse markers of endothelial dysfunction. Therefore, we did not demonstrate an effect of nicotinamide on reducing markers of preeclampsia from primary human placental tissues and vascular cells.

Identifiants

DOI: 10.1016/j.placenta.2021.04.007 PMID: 33957335
pubmed: 33957335
pii: S0143-4004(21)00122-3
doi: 10.1016/j.placenta.2021.04.007
pii:
doi:

Substances chimiques

Angiogenesis Inhibitors 0
Niacinamide 25X51I8RD4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

28-31

Informations de copyright

Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.

Auteurs

Fiona Brownfoot (F)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia. Electronic address: Fiona.brownfoot@unimelb.edu.au.

Natalie Binder (N)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Roxanne Hastie (R)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Alesia Harper (A)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Sally Beard (S)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Laura Tuohey (L)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Emerson Keenan (E)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Stephen Tong (S)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

Natalie Hannan (N)

Mercy Perinatal, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia; Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, University of Melbourne. Mercy Perinatal, Mercy Hospital for Women 163 Studley Rd, Heidelberg, 3084, Victoria, Australia.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de l'angiogenèse › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Cellules › Cellules cultivées › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nicotinamide › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Structures de l'embryon › Placenta › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Nicotinamide and its effects on endothelial...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Nicotinamide and its effects on endothelial...