Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature.
Local neoplasm recurrences
Neuroendocrine carcinoma
Prostate neoplasms
Prostatectomy
Journal
Journal of medical case reports
ISSN: 1752-1947
Titre abrégé: J Med Case Rep
Pays: England
ID NLM: 101293382
Informations de publication
Date de publication:
07 May 2021
07 May 2021
Historique:
received:
29
06
2020
accepted:
26
03
2021
entrez:
7
5
2021
pubmed:
8
5
2021
medline:
13
5
2021
Statut:
epublish
Résumé
Primitive neuroendocrine prostate neoplasms are rarely reported. This entity comprises carcinoïd tumors and poorly differentiated neuroendocrine tumors, mainly those of the small-cell type. Large-cell-type primitive tumors are exceptional, and only nine cases are reported in the literature. Similar to neuroendocrine tumors of the prostate, large-cell-type primitive tumors may be observed in the context of conventional adenocarcinoma during androgen deprivation therapy or as prostatic metastasis of a distant neuroendocrine tumor, mainly pulmonary neoplasms. We report a Caucasian case of a mixed prostatic carcinoma, with the largest component being the large-cell neuroendocine carcinoma, in a patient who underwent a total prostatectomy for a localized cancer. Diagnostic, histological, therapeutic and evolutive aspects are reported and discussed. Large-cell primitive prostate neuroendocrine carcinoma is a rare but aggressive histological entity, which can be associated or not with an adenocarcinomatous component. Mixed forms have a better outcome, mainly when diagnosed at an early stage.
Sections du résumé
BACKGROUND
BACKGROUND
Primitive neuroendocrine prostate neoplasms are rarely reported. This entity comprises carcinoïd tumors and poorly differentiated neuroendocrine tumors, mainly those of the small-cell type. Large-cell-type primitive tumors are exceptional, and only nine cases are reported in the literature. Similar to neuroendocrine tumors of the prostate, large-cell-type primitive tumors may be observed in the context of conventional adenocarcinoma during androgen deprivation therapy or as prostatic metastasis of a distant neuroendocrine tumor, mainly pulmonary neoplasms.
CASE PRESENTATION
METHODS
We report a Caucasian case of a mixed prostatic carcinoma, with the largest component being the large-cell neuroendocine carcinoma, in a patient who underwent a total prostatectomy for a localized cancer. Diagnostic, histological, therapeutic and evolutive aspects are reported and discussed.
CONCLUSIONS
CONCLUSIONS
Large-cell primitive prostate neuroendocrine carcinoma is a rare but aggressive histological entity, which can be associated or not with an adenocarcinomatous component. Mixed forms have a better outcome, mainly when diagnosed at an early stage.
Identifiants
pubmed: 33957979
doi: 10.1186/s13256-021-02830-5
pii: 10.1186/s13256-021-02830-5
pmc: PMC8103761
doi:
Substances chimiques
Androgen Antagonists
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
254Références
Endocr Pathol. 2016 Jun;27(2):123-35
pubmed: 26885643
Am J Surg Pathol. 2006 Jun;30(6):684-93
pubmed: 16723845
Hum Pathol. 2019 Mar;85:313-327
pubmed: 30481509
N Engl J Med. 2011 May 26;364(21):1995-2005
pubmed: 21612468
Prostate. 1999 May;39(2):135-48
pubmed: 10221570
N Engl J Med. 2012 Sep 27;367(13):1187-97
pubmed: 22894553
Eur Urol. 2016 Jul;70(1):106-119
pubmed: 26996659
J Cancer Res Ther. 2018 Sep;14(Supplement):S785-S788
pubmed: 30249904
Int J Clin Exp Pathol. 2014 Dec 01;7(12):9061-6
pubmed: 25674288
Urol Int. 2019;103(4):383-390
pubmed: 30965328
Am J Surg Pathol. 2014 Jun;38(6):756-67
pubmed: 24705311
Mod Pathol. 2018 Jan;31(S1):S122-132
pubmed: 29297494
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15382-7
pubmed: 9860977